CAS 1486471-13-9

Belinostat Glucuronide

Description:

Belinostat glucuronide is a chemical compound that serves as a metabolite of belinostat, a histone deacetylase inhibitor used in cancer therapy. This substance is characterized by its glucuronidation, a biochemical process where a glucuronic acid moiety is conjugated to a parent drug, enhancing its solubility and facilitating excretion. The compound is typically studied in the context of pharmacokinetics and drug metabolism, as it reflects the body's processing of belinostat. Belinostat itself is known for its role in inducing cell cycle arrest and apoptosis in cancer cells, particularly in hematological malignancies. The glucuronide form may exhibit altered pharmacological properties compared to its parent compound, including differences in efficacy and toxicity. Understanding the characteristics of belinostat glucuronide is crucial for optimizing therapeutic strategies and minimizing adverse effects in clinical settings. As with many metabolites, its stability, solubility, and interaction with biological systems are key factors in determining its overall impact on drug efficacy and safety.

Formula: C₂₁H₂₂N₂O₁₀S

Synonyms:

• Belinostat M1
• β-D-Glucopyranuronic acid, 1-O-[[(2E)-1-oxo-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propen-1-yl]amino]-
• Belinostat Impurity 1 (Belinostat Glucuronide)
• Belinostat Glucuronide

Belinostat Glucuronide

CAS: 1486471-13-9

Formula: C₂₁H₂₂N₂O₁₀S

Color and Shape: White To Off-White Solid

Molecular weight: 494.47

Ref: 4Z-B-130013

Belinostat-d5 Glucuronide

CAS: 1486471-13-9

Formula: C₂₁H₁₇D₅N₂O₁₀S

Color and Shape: White To Off-White Solid

Molecular weight: 499.50

Ref: 4Z-B-130014

Belinostat Glucuronide

Controlled Product

CAS: 1486471-13-9

Applications Belinostat Glucuronide is the major metabolite of Belinostat. Belinostat (B131400) is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.
References Wang, L., et al.: PLoS One, 8, 54522 (2013); Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);

Formula: C₂₁H₂₂N₂O₁₀S

Color and Shape: Neat

Molecular weight: 494.47

Ref: TR-B131405

Belinostat Glucuronide-d5

Controlled Product

CAS: 1486471-13-9

Formula: C₂₁D₅H₁₇N₂O₁₀S

Color and Shape: Neat

Molecular weight: 499.503

Ref: TR-B131407

Belinostat glucuronide

CAS: 1486471-13-9

Belinostat glucuronide is an analytical standard that is used in HPLC. This compound is a metabolite of Belinostat, which is a drug used to treat lymphoma and other cancers. Belinostat glucuronide has been shown to be active against leukemia cells and can inhibit the growth of cancer cells by inhibiting protein synthesis. It also inhibits the activity of topoisomerase I, II, and III.

Formula: C₂₁H₂₂N₂O₁₀S

Purity: Min. 95%

Molecular weight: 494.50 g/mol

Ref: 3D-LJC47113

Belinostat Glucuronide

CAS: 1486471-13-9

Belinostat Glucuronide, a main metabolite of Belinostat, inhibits HDAC3 and prevents β cell death by cytokines.

Formula: C₂₁H₂₂N₂O₁₀S

Color and Shape: Solid

Molecular weight: 494.47

Ref: TM-T70560