CAS 14897-39-3

Rifamycin sodium

Description:

Rifamycin sodium is an antibiotic compound primarily used in the treatment of bacterial infections, particularly those caused by Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. It belongs to the rifamycin class of antibiotics, which are characterized by their ability to inhibit bacterial RNA synthesis by binding to the DNA-dependent RNA polymerase enzyme. This mechanism of action makes rifamycins effective against a broad spectrum of gram-positive and some gram-negative bacteria. Rifamycin sodium is typically administered in its sodium salt form to enhance solubility and bioavailability. It is often used in combination with other antitubercular agents to prevent the development of drug resistance. The compound is known for its potential side effects, which can include liver toxicity and interactions with other medications due to its effect on liver enzymes. Additionally, it is important to monitor patients for signs of hypersensitivity reactions. Overall, rifamycin sodium is a critical component in the management of tuberculosis and other bacterial infections, contributing significantly to public health efforts against these diseases.

Formula: C₃₇H₄₆NNaO₁₂

InChI: InChI=1/C37H47NO12.Na.H/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);;/b11-10-,14-13-,17-12u;;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;;/m0../s1/rC37H47NO12.HNa/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);1H/b11-10-,14-13-,17-12u;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1

InChI key: InChIKey=URCDBMLCEGDNOK-NLYBMVFSSA-N

SMILES: O=C1C=2C=3C4=C(O)C(=CC3O)NC(=O)\C(\C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2C(C)=C4O.[Na]

Synonyms:

• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, sodium salt
• Cb 01-11
• Monosodium rifamycin SV
• NSC 146718
• Rifamycin SV Monosodium
• Rifamycin SV sodium salt
• Rifamycin Sodium
• Rifamycin sodium salt
• Rifamycin, monosodium salt
• Rifamycin, sodium salt (1:1)
• Tuborin
• RIFAMPICIN SV SODIUM
• Rifamycin SV hexahydrate sodium salt
• 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, monosodium salt
• (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione sodium salt
• Rifamycin SV s
• Rifamycinsodiumsal
• Rifamycin Sodium USP/EP/BP
• Rifamycin Na USP/EP/BP
• RIFAMYCIN,MONOSODIUMSALT
• 5,6,9,17,19,21-Hexahydroxy-23-Methoxy-2,4,12,16,18,20,22-heptaMethyl-
• Rifamycin sodium CRS
• Rifamycin SV sodium, >=900 IU/mg
• RIFAMYCIN SV SODIUM SALT HEXAHYDRATE
• RifaMycin SV MonosodiuM salt
• RIFAMYCIN SV-SODIUM

Rifamycin SV sodium, 98+%

CAS: 14897-39-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₃₇H₄₆NNaO₁₂

Purity: 98+%

Color and Shape: Red, Crystalline powder

Molecular weight: 719.45

Ref: 02-J63095

RIFAMYCIN SODIUM CRS

CAS: 14897-39-3

RIFAMYCIN SODIUM CRS

Formula: C₃₇H₄₆NNaO₁₂

Molecular weight: 719.7504

Ref: 41-R1000000

FIRST INTERNATIONAL STANDARD FOR RIFAMYCIN SV

CAS: 14897-39-3

FIRST INTERNATIONAL STANDARD FOR RIFAMYCIN SV

Formula: C₃₇H₄₆NNaO₁₂

Molecular weight: 719.7504

Ref: 41-ISA_66_231

2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, sodium salt

CAS: 14897-39-3

Formula: C₃₇H₄₇NNaO₁₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 720.7584

Ref: IN-DA001LAU

Rifamycin sodium

CAS: 14897-39-3

Rifamycin sodium

Purity: ≥95%

Molecular weight: 719.75g/mol

Ref: 54-BUP11801

Rifaximin EP Impurity C Sodium Salt (Rifamycin SV Sodium Salt)

CAS: 14897-39-3

Formula: C₃₇H₄₆NO₁₂·Na

Color and Shape: Red Solid

Molecular weight: 696.77 22.99

Ref: 4Z-R-3513

Rifamycin sodium salt

CAS: 14897-39-3

Formula: C₃₇H₄₆NNaO₁₂

Color and Shape: Orange, red or brown-red powder

Molecular weight: 719.45

Ref: 7W-GA6855

Rifamycin Sodium

CAS: 14897-39-3

Rifamycin Sodium

Purity: 97%

Molecular weight: 720.76g/mol

Ref: 54-OR1028410

Rifamycin Sodium (Rifamycin SV Sodium)

CAS: 14897-39-3

Color and Shape: Red

Ref: 86-MM3747.00

Rifamycin sodium

CAS: 14897-39-3

Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase.

Formula: C₃₇H₄₆NNaO₁₂

Purity: 97.72%

Color and Shape: Coa

Molecular weight: 719.75

Ref: TM-T5003

Rifamycin SV Sodium

CAS: 14897-39-3

Impurity Rifaximin EP Impurity C
Applications Rifamycin SV Sodium (Rifaximin EP Impurity C) is a semi-synthetic antibiotic derived from Rifamycin S. (1) Antibacterial (2). Potency >900 units (dry basis).
References 1. Sensi, P. et al.: Experientia. 1960 Sep 15;16:412.2. Mascherpa, P., et al.: Biochem. Pharmacol. 1966 Feb;15(2):200-4.

Formula: C₃₇H₄₆NO₁₂·Na

Color and Shape: Red

Molecular weight: 719.75

Ref: TR-R508200

Rifaximin EP Impurity C

CAS: 14897-39-3

Formula: C₃₇H₄₆NO₁₂Na

Molecular weight: 696.8 : 23.0

Ref: ST-EA-CP-R42008

Rifamycin SV sodium

CAS: 14897-39-3

Rifamycin SV sodium is a hydroxide solution of the antibiotic rifamycin. Rifamycin SV sodium inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Rifapentine also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Formula: C₃₇H₄₆NNaO₁₂

Purity: Min 900U/Mg

Color and Shape: Powder

Molecular weight: 719.75 g/mol

Ref: 3D-FR27730

Rifamycin SV sodium - Bio-X ™

CAS: 14897-39-3

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₇H₄₆NNaO₁₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 719.75 g/mol

Ref: 3D-BR300118

Rifamycin sodium

CAS: 14897-39-3

Molecular weight: 719.76

Ref: 10-F986312