CAS 149690-05-1

Sacubitril Sodium

Description:

Sacubitril sodium is a pharmaceutical compound primarily used in the treatment of heart failure. It functions as a neprilysin inhibitor, which enhances the levels of natriuretic peptides, leading to vasodilation and diuresis. This mechanism helps to reduce the strain on the heart and improve overall cardiac function. Sacubitril sodium is typically administered in combination with valsartan, an angiotensin receptor blocker, to provide a synergistic effect in managing heart failure. The compound is characterized by its sodium salt form, which enhances its solubility and bioavailability. In terms of physical properties, sacubitril sodium is a white to off-white powder, and it is soluble in water. Its pharmacokinetics involve rapid absorption and metabolism, with a half-life that supports once or twice daily dosing. As with any medication, potential side effects may include hypotension, hyperkalemia, and renal impairment, necessitating careful monitoring during treatment. Overall, sacubitril sodium represents a significant advancement in heart failure management, improving patient outcomes through its unique mechanism of action.

Synonyms:

• Sacubitril Sodium Salt

Sacubitril Sodium Salt

CAS: 149690-05-1

Formula: C₂₄H₂₈NO₅·Na

Molecular weight: 410.49 22.99

Ref: 4Z-S-072077

Sacubitril sodium

CAS: 149690-05-1

Sacubitril sodium

Purity: ≥98%

Molecular weight: 433.47g/mol

Ref: 54-BUP20879

Sacubitril Sodium

CAS: 149690-05-1

Color and Shape: Neat

Ref: 86-MM3969.01

Sacubitril sodium

CAS: 149690-05-1

Sacubitril sodium (AHU-377) is potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.

Formula: C₂₄H₂₈NNaO₅

Purity: 99.97%

Color and Shape: Solid

Molecular weight: 433.47

Ref: TM-T4574L

Sacubitril Sodium Salt

CAS: 149690-05-1

Formula: C₂₄H₂₈NO₅·Na

Color and Shape: White To Off-White

Molecular weight: 433.473

Ref: TR-S080960

Sacubitril sodium

CAS: 149690-05-1

Inhibitor of metalloendopeptidase neprilysin

Formula: C₂₄H₂₈NNaO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 433.47 g/mol

Ref: 3D-FS165528

Sacubitril-13C4 Sodium

Controlled Product

CAS: 149690-05-1

Applications Sacubitril-13C4 Sodium is a derivative Isotope labelled Sacubitril (S080895), which is an antihypertensive drug used in combination with Valsartan (V095750). The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

Formula: C₄C₂₀H₂₈NNaO₅

Color and Shape: Neat

Molecular weight: 437.443

Ref: TR-S080952