CAS 149697-16-5

Z-ALA-ALA-ASN-AMC

Description:

Z-ALA-ALA-ASN-AMC, with the CAS number 149697-16-5, is a synthetic peptide substrate commonly used in biochemical research, particularly in the study of proteases. This compound consists of a sequence of amino acids, specifically Z (which denotes a protective group), alanine (Ala), asparagine (Asn), and an AMC (7-amino-4-methylcoumarin) moiety, which serves as a fluorescent reporter. The Z group typically protects the amino group of the first alanine, enhancing the stability and specificity of the peptide. The presence of the AMC group allows for the quantification of enzymatic activity through fluorescence, making it a valuable tool in enzyme assays. Z-ALA-ALA-ASN-AMC is often utilized in studies involving serine proteases and other enzymes that cleave peptide bonds, providing insights into enzyme kinetics and mechanisms. Its characteristics include solubility in aqueous solutions, stability under physiological conditions, and the ability to produce a measurable fluorescent signal upon cleavage, facilitating real-time monitoring of enzymatic reactions.

Formula: C₂₈H₃₁N₅O₈

Synonyms:

• Benzyloxycarbonyl-L-Alanyl-L-Alanyl-L-Asparagine 4-Methylcoumaryl-7-Amide
• Z-Aan-Amc
• Z-Ala-Ala-Asn-Mca
• L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• Z-ALA-ALA-ASN-AMC

Z-Ala-Ala-Asn-AMC

CAS: 149697-16-5

Z-AAN-AMC, standard substrate for legumain (EC 3.4.22.34), was originally used for the plant enzyme and later to discover the mammalian form of the enzyme. Legumain may be a physiologic local regulator of human osteoclast (OCL) activity that can negatively modulate OCL.

Formula: C₂₈H₃₁N₅O₈

Purity: ≥ 99%

Color and Shape: Yellowish Powder

Molecular weight: 565.58

Ref: 01-4033201

Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate

CAS: 149697-16-5

Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate

Purity: 99%

Molecular weight: 565.58g/mol

Ref: 54-OR1074609

Z-Ala-Ala-Asn-AMC

CAS: 149697-16-5

Z-Ala-Ala-Asn-AMC is a peptide that can be used as an inhibitor, activator, or ligand for protein interactions. It is also a research tool and antibody production reagent. This compound has high purity and is suitable for both in vitro and in vivo research.

Formula: C₂₈H₃₁N₅O₈

Purity: Min. 95%

Molecular weight: 565.57 g/mol

Ref: 3D-MCA-3209-V

Z-Ala-Ala-Asn-AMC

CAS: 149697-16-5

Z-Ala-Ala-Asn-AMC is a molecule that is an analog of the amino acid alanine. It has been shown to be effective in inhibiting cancer cell viability and inducing apoptosis in MDA-MB-231 breast cancer cells, which can inhibit tumor growth. This molecule also inhibits protease activity, protein synthesis, and tubule cell proliferation. Z-Ala-Ala-Asn-AMC has applicability in the treatment of cancers and inflammatory diseases.

Formula: C₂₈H₃₁N₅O₈

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 565.57 g/mol

Ref: 3D-FA110589