CAS 149845-07-8

Tiludronate disodium

Description:

Tiludronate disodium is a bisphosphonate compound primarily used in the treatment of Paget's disease and other bone disorders. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The substance is characterized by its disodium salt form, which enhances its solubility in aqueous solutions, facilitating its administration. Tiludronate disodium is typically administered orally and is known for its relatively low gastrointestinal side effects compared to other bisphosphonates. Its chemical structure features two phosphonate groups, which are essential for its biological activity, allowing it to bind to hydroxyapatite in bone tissue. The compound is generally well-tolerated, but like other bisphosphonates, it may be associated with rare adverse effects such as osteonecrosis of the jaw or atypical femoral fractures. Overall, Tiludronate disodium plays a significant role in managing conditions associated with abnormal bone metabolism, contributing to improved patient outcomes in bone health.

Formula: C₇H₉ClO₆P₂S·2Na

InChI: InChI=1S/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;

InChI key: InChIKey=CLNKSBSNCRWXKR-UHFFFAOYSA-N

SMILES: C(SC1=CC=C(Cl)C=C1)(P(=O)(O)O)P(=O)(O)O.[Na]

Synonyms:

• Disodium (4-chlorophenylthio)methylenediphosphonate
• Disodium tiludronate
• Disodium {[(4-Chlorophenyl)Sulfanyl]Methanediyl}Bis[Hydrogen (Phosphonate)]
• Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, disodium salt
• Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, sodium salt (1:2)
• Skelid
• Sr 41319G
• Sr-41319B
• Tiludronate disodium
• [[(4-Chlorophenyl)Thio]Methylene]Biphosphonic Acid, Disodium Salt
• [[(4-Chlorophenyl)thio]methylene]biphosphonicAcid,DisodiumSalt,SR-41319B,Skelid

Disodium Tiludronate

CAS: 149845-07-8, 89987-06-4

Formula: C₇H₇ClNa₂O₆P₂S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 362.56

Ref: 3B-D4167

Tiludronate (disodium)

CAS: 149845-07-8

Formula: C₇H₇ClNa₂O₆P₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 362.5719

Ref: IN-DA001M1S

Tiludronate disodium

CAS: 149845-07-8

Tiludronate disodium

Purity: ≥98%

Molecular weight: 362.57g/mol

Ref: 54-BUP10287

Tiludronic Acid Disodium Salt

CAS: 149845-07-8, 89987-06-4

Formula: C₇H₇ClO₆P₂S·2Na

Molecular weight: 316.59 2 22.99

Ref: 4Z-T-260001

Tiludronic Acid-d5 Disodium Salt

Controlled Product

CAS: 149845-07-8

Applications Labelled Tiludronic Acid (T441250). A biphosphonate bone resorption inhibitor.
References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),

Formula: C₇H₂D₅ClNa₂O₆P₂S

Color and Shape: Neat

Molecular weight: 367.6

Ref: TR-T441252

Tiludronic Acid Disodium Salt

CAS: 149845-07-8

Applications A biphosphonate bone resorption inhibitor.
References Fraser, W.D., et al.: Postgrad. Med. J., 73, 496 (1997),

Formula: C₇H₇ClO₆P₂S·2Na

Color and Shape: Off-White

Molecular weight: 362.57

Ref: TR-T441250

Tiludronic acid disodium

CAS: 149845-07-8

Farnesyltransferase inhibitor

Formula: C₇H₉ClO₆P₂S•Na₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 364.59 g/mol

Ref: 3D-FT28278

Tiludronate disodium

CAS: 149845-07-8

Tiludronate disodium: osteoclast inhibitor for metabolic bone disorder research.

Formula: C₇H₇ClNa₂O₆P₂S

Purity: >99.99% - >99.99%

Color and Shape: Fine White To Off-White Crystalline Powder

Molecular weight: 362.57

Ref: TM-T13159