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CAS 89987-06-4

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Tiludronate

Description:
Tiludronate is a bisphosphonate compound primarily used in the treatment of Paget's disease of bone and osteoporosis. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The chemical structure of tiludronate includes two phosphonate groups, which are essential for its biological activity. It is typically administered orally and has a relatively low bioavailability, necessitating specific dosing regimens. The substance is known for its ability to bind to hydroxyapatite in bone, which enhances its therapeutic effects. Common side effects may include gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw. Tiludronate is classified as a non-nitrogen-containing bisphosphonate, distinguishing it from other bisphosphonates that contain nitrogen in their structure. Its mechanism of action and therapeutic applications make it a significant agent in managing bone-related disorders. As with any medication, it is essential to consider contraindications and potential interactions with other drugs when prescribing tiludronate.
Formula:C7H9ClO6P2S
InChI:InChI=1S/C7H9ClO6P2S/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14/h1-4,7H,(H2,9,10,11)(H2,12,13,14)
InChI key:InChIKey=DKJJVAGXPKPDRL-UHFFFAOYSA-N
SMILES:C(SC1=CC=C(Cl)C=C1)(P(=O)(O)O)P(=O)(O)O
Synonyms:
  • Tiludronic acid
  • SR 41319
  • Phosphonic acid, P,P′-[[(4-chlorophenyl)thio]methylene]bis-
  • Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-
  • P,P′-[[(4-Chlorophenyl)thio]methylene]bis[phosphonic acid]
Found 7 products.