CAS 149845-07-8: Tiludronate disodium
Description:Tiludronate disodium is a bisphosphonate compound primarily used in the treatment of Paget's disease and other bone disorders. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The substance is characterized by its disodium salt form, which enhances its solubility in aqueous solutions, facilitating its administration. Tiludronate disodium is typically administered orally and is known for its relatively low gastrointestinal side effects compared to other bisphosphonates. Its chemical structure features two phosphonate groups, which are essential for its biological activity, allowing it to bind to hydroxyapatite in bone tissue. The compound is generally well-tolerated, but like other bisphosphonates, it may be associated with rare adverse effects such as osteonecrosis of the jaw or atypical femoral fractures. Overall, Tiludronate disodium plays a significant role in managing conditions associated with abnormal bone metabolism, contributing to improved patient outcomes in bone health.
Formula:C7H9ClO6P2S·2Na
InChI:InChI=1S/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;
InChI key:InChIKey=CLNKSBSNCRWXKR-UHFFFAOYSA-N
SMILES:[Na].O=P(O)(O)C(SC1=CC=C(Cl)C=C1)P(=O)(O)O
- Synonyms:
- Disodium (4-chlorophenylthio)methylenediphosphonate
- Disodium tiludronate
- Disodium {[(4-Chlorophenyl)Sulfanyl]Methanediyl}Bis[Hydrogen (Phosphonate)]
- Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, disodium salt
- Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, sodium salt (1:2)
- Skelid
- Sr 41319G
- Sr-41319B
- Tiludronate disodium
- [[(4-Chlorophenyl)Thio]Methylene]Biphosphonic Acid, Disodium Salt
- See more synonyms
- [[(4-Chlorophenyl)thio]methylene]biphosphonicAcid,DisodiumSalt,SR-41319B,Skelid
![Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-, sodium salt (1:2)](https://static.cymitquimica.com/products/IN/thumb/DA001M1S.jpg)
