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CAS 1501-84-4

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Rimantadine hydrochloride

Description:
Rimantadine hydrochloride is an antiviral medication primarily used for the prevention and treatment of influenza A virus infections. It is classified as an adamantane derivative, which works by inhibiting the viral replication process. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for oral administration. Rimantadine hydrochloride has a relatively low molecular weight and exhibits a moderate pKa, indicating its weak basicity. Its mechanism of action involves blocking the M2 ion channel of the influenza virus, thereby preventing the uncoating of the viral particle and subsequent release of viral RNA into the host cell. The drug is generally well-tolerated, but it may cause side effects such as gastrointestinal disturbances, dizziness, and insomnia. Due to the emergence of resistant strains of the influenza virus, the efficacy of rimantadine has been limited in recent years, prompting the development of alternative antiviral agents.
Formula:C12H21N·ClH
InChI:InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
InChI key:InChIKey=OZBDFBJXRJWNAV-UHFFFAOYSA-N
SMILES:C(C)(N)C12CC3CC(C1)CC(C2)C3.Cl
Synonyms:
  • 1-(1-Aminoethyl)adamantane hydrochloride
  • 1-(Adamantan-1-yl)ethan-1-amine hydrochloride
  • 1-(Tricyclo[3.3.1.1~3,7~]Dec-1-Yl)Ethanamine Hydrochloride (1:1)
  • 1-Adamantane ethylamine hydrochloride
  • 1-Adamantanemethylamine, α-methyl-, hydrochloride
  • Exp 126
  • Flumadine
  • Jp 61
  • Meradan
  • Meradane
  • See more synonyms
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