CAS 150113-99-8

Decanoyl-Arg-Val-Arg-Lys-chloromethylketone

Description:

Decanoyl-Arg-Val-Arg-Lys-chloromethylketone is a synthetic peptide derivative characterized by its specific amino acid sequence and a chloromethylketone functional group. This compound features a decanoyl group, which is a fatty acid chain that enhances its lipophilicity, potentially facilitating membrane permeability. The presence of arginine, valine, and lysine in its sequence suggests that it may exhibit biological activity, possibly related to cell signaling or antimicrobial properties. The chloromethylketone moiety is known for its ability to form covalent bonds with nucleophiles, which can be significant in biochemical applications, such as enzyme inhibition or as a reactive probe in protein studies. Overall, this compound is of interest in biochemical research and may have applications in drug development or as a tool for studying protein interactions. However, its specific biological effects and mechanisms would require further investigation through empirical studies.

Formula: C₃₄H₆₆ClN₁₁O₅

Synonyms:

• Decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Decanoyl-Arg-Val-Lys-Arg-chloromethylketone

CAS: 150113-99-8

Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that Dec-RVKR-CMK decreased the production of β-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Apart from furin, Dec-RVKR-CMK also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).

Formula: C₃₄H₆₆ClN₁₁O₅

Purity: 90.2%

Color and Shape: White Powder

Molecular weight: 744.42

Ref: 01-4026850

N-((6S,9S,12S,15S)-1,20-Diamino-9-(4-aminobutyl)-6-(2-chloroacetyl)-1,20-diimino-12-isopropyl-8,11,14-trioxo-2,7,10,13,19-pentaazaicosan-15-yl)decanamide

CAS: 150113-99-8

N-((6S,9S,12S,15S)-1,20-Diamino-9-(4-aminobutyl)-6-(2-chloroacetyl)-1,20-diimino-12-isopropyl-8,11,14-trioxo-2,7,10,13,19-pentaazaicosan-15-yl)decanamide

Purity: 95%

Molecular weight: 744.43g/mol

Ref: 54-OR1073260

Decanoyl-RVKR-CMK

CAS: 150113-99-8

Inhibits all seven proprotein convertases; stops proET-1 processing; hinders VGF secretion in PC12 cells.

Formula: C₃₄H₆₆ClN₁₁O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 744.42

Ref: TM-TP2038