CAS 150683-30-0

Tolvaptan

Description:

Tolvaptan is a selective vasopressin V2 receptor antagonist primarily used in the treatment of conditions such as hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). It is a small organic molecule characterized by its ability to inhibit the action of vasopressin, a hormone that regulates water retention in the kidneys. This inhibition leads to increased urine output and a subsequent rise in serum sodium levels. Tolvaptan is typically administered orally and is known for its relatively high bioavailability. The substance is classified as a non-peptide antagonist and has a specific molecular structure that contributes to its pharmacological properties. Common side effects may include thirst, dry mouth, and potential liver function abnormalities, necessitating regular monitoring during treatment. Due to its mechanism of action, Tolvaptan is particularly beneficial in managing fluid overload conditions, making it a valuable therapeutic agent in nephrology and endocrinology.

Formula: C₂₆H₂₅ClN₂O₃

InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

InChI key: InChIKey=GYHCTFXIZSNGJT-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(=CC(Cl)=CC2)C(O)CCC1)C3=C(C)C=C(NC(=O)C4=C(C)C=CC=C4)C=C3

Synonyms:

• 1-[4-(2-Methylbenzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol
• 1H-1-Benzazepine, benzamide deriv.
• Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-
• Jinarc
• Jynarque
• N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide
• N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide
• N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide
• N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
• N-{4-[(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide
• Opc 41061
• Samsca

Tolvaptan

CAS: 150683-30-0

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₂₆H₂₅ClN₂O₃

Color and Shape: White Powder

Molecular weight: 448.15537

Ref: 45-1672060

Tolvaptan

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 448.94

Ref: 7W-GP7013

Tolvaptan

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 448.95

Ref: 4Z-T-691

Tolvaptan

Controlled Product

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Color and Shape: Neat

Molecular weight: 448.94

Ref: 86-MM3561.00

Tolvaptan

Controlled Product

CAS: 150683-30-0

Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);

Formula: C₂₆H₂₅ClN₂O₃

Color and Shape: Neat

Molecular weight: 448.94

Ref: TR-T536650

Tolvaptan

CAS: 150683-30-0

Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.

Formula: C₂₆H₂₅ClN₂O₃

Purity: 99.78% - >99.99%

Color and Shape: Solid

Molecular weight: 448.94

Ref: TM-T2326

Tolvaptan RS

CAS: 150683-30-0

Color and Shape: White Crystals Or Crystalline Powder

Ref: 2K-109810002

Tolvaptan

CAS: 150683-30-0

Formula: C₂₆H₂₅ClN₂O₃

Molecular weight: 448.95

Ref: ST-EA-CP-T26000

N-(4-(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide

CAS: 150683-30-0

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 448.95001220703125

Ref: 10-F361970

Tolvaptan

Controlled Product

CAS: 150683-30-0

Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.

Formula: C₂₆H₂₅ClN₂O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 448.94 g/mol

Ref: 3D-FT34175

Tolvaptan - Bio-X ™

Controlled Product

CAS: 150683-30-0

Tolvaptan is a vasopressin receptor antagonist. It binds to the V2 receptor in the cytosol and prevents it from activating the aquaporin 2 channel, which regulates water permeability. Inhibition of vasopressin receptors in the kidneys improves fluid and electrolyte balance. Tolvaptan has been shown to be effective for treating congestive heart failure, as well as other disorders that are associated with fluid retention, such as renal dysfunction and metabolic syndrome. Tolvaptan can also be used in combination therapy with other drugs to treat these conditions.

Formula: C₂₆H₂₅ClN₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 448.94 g/mol

Ref: 3D-BT164486

Tolvaptan RS

CAS: 150683-30-0

Color and Shape: White Crystals Or Crystalline Powder

Ref: 2K-1098100021