CAS 152-58-9

11-Deoxycortisol

Description:

11-Deoxycortisol, also known as cortodoxone, is a steroid hormone that plays a significant role in the biosynthesis of corticosteroids. It is classified as a glucocorticoid and is produced in the adrenal cortex. The chemical structure of 11-Deoxycortisol features a steroid backbone, characterized by four fused carbon rings, with specific functional groups that contribute to its biological activity. It is a precursor in the synthesis of cortisol, which is crucial for regulating metabolism, immune response, and stress response in the body. The CAS number 152-58-9 uniquely identifies this compound in chemical databases. In terms of solubility, 11-Deoxycortisol is generally lipophilic, allowing it to easily cross cell membranes and exert its effects on target tissues. Its biological activity is mediated through binding to glucocorticoid receptors, influencing gene expression and cellular functions. Due to its role in the endocrine system, alterations in 11-Deoxycortisol levels can be indicative of various health conditions, including adrenal insufficiency or hyperplasia.

Formula: C₂₁H₃₀O₄

InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

InChI key: InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
• (8Xi,9Xi,10Xi,13Xi,14Xi)-17,21-Dihydroxypregn-4-Ene-3,20-Dione
• 11-Deoxy-17-hydrocorticosterone
• 11-Deoxy-17-hydroxycorticosterone
• 11-Deoxycortisol
• 11-Deoxycortisone
• 11-Deoxyhydrocortisone
• 11-Desoxy-17-hydroxycorticosterone
• 11-Desoxy-17α-hydroxycorticosterone
• 11-Desoxycortisol
• 11-Desoxycortisone
• 11-Desoxyhydrocortisone
• 11-Dioxycortisol
• 17,21-Dihydroxy-4-pregnene-3,20-dione
• 17,21-Dihydroxy-Pregn-4-Ene-3,20-Dione
• 17,21-Dihydroxypregn-4-en-3,20-dione
• 17,21-Dihydroxypregn-4-ene-3,20-dione
• 17,21-Dihydroxyprogesterone
• 17-Hydroxy-11-deoxycorticosterone
• 17alpha,21-Dihydroxypregn-4-ene-3,20-dione
• 17Α,21-Dihydroxypregn-4-Ene-3,20-Dione
• 17α,21-Dihydroxy-4-pregnen-3,20-dion
• 17α,21-Dihydroxy-4-pregnen-3,20-dione
• 17α,21-Dihydroxyprogesterone
• 17α-Hydroxycortexone
• 4-Pregnen-17α,21-diol-3,20-dion
• 4-Pregnen-17α,21-diol-3,20-dione
• 4-Pregnene-11β,17,21-triol-3,20-dione
• 4-Pregnene-17α, 21-diol-3,20-dione
• Compound S
• Corticosterone, 11-deoxy-17-hydroxy-
• Cortifen
• Cortisol, 11-deoxy-
• Cortisol, 11-dioxy-
• Cortodoxon
• Cortodoxona
• Cortodoxone
• Nsc 18317
• Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
• Reichstein S
• Reichstein substance S
• Reichstein's Substanz S
• Reichstein's compound S
• Reichstein's substance S
• Sk&F 3050
• Skf 3050
• Substance S
• cortodoxone (INN)
• Δ4-Pregnene-17α,21-diol-3,20-dione
• Δ⁴-Pregnene-17α,21-diol-3,20-dione

Cortexolone

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 346.47

Ref: 3B-C1478

11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) 1.0 mg/ml in Methanol

CAS: 152-58-9

Color and Shape: Single Solution

Ref: 61-AMP0185.08-01

11-Deoxycortisol, 1mg/ml in Acetonitrile

CAS: 152-58-9

Color and Shape: Single Solution

Ref: LP-COR-1627-1LA

Cortodoxone (17,21-Dihydroxypregn-4-ene-3,20-dione)

CAS: 152-58-9

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₁H₃₀O₄

Color and Shape: White Powder

Molecular weight: 346.21441

Ref: 45-1A11650

Cortodoxone

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 346.4605

Ref: IN-DA003P2I

Cortexolone (Hydrocortisone EP Impurity F)

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Molecular weight: 346.47

Ref: 4Z-C-502001

Cortexolone

CAS: 152-58-9

Cortexolone

Purity: 98%

Molecular weight: 346.47g/mol

Ref: 54-OR1029721

Cortodoxone

CAS: 152-58-9

Cortodoxone

Purity: ≥98%

Molecular weight: 346.46g/mol

Ref: 54-BUP00016

Reichsteins substance S

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 346.46

Ref: 7W-GK2007

17,21-Dihydroxypregn-4-ene-3,20-dione (Reichstein's Substance S)

Controlled Product

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Color and Shape: White To Off-White

Molecular weight: 346.46

Ref: 86-MM0185.08

11-Deoxycortisol

CAS: 152-58-9

Color and Shape: Neat

Ref: LP-COR-1627-10

Cortodoxone

CAS: 152-58-9

Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

Formula: C₂₁H₃₀O₄

Purity: 99.26% - 99.87%

Color and Shape: Solid

Molecular weight: 346.46

Ref: TM-T2748

Cortexolone-d5 (Hydrocortisone EP Impurity F-d5)

CAS: 152-58-9

Formula: C₂₁H₂₅D₅O₄

Molecular weight: 351.50

Ref: 4Z-C-502002

17,21-Dihydroxy-pregn-4-ene-3,20-dione

CAS: 152-58-9

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 346.4670104980469

Ref: 10-F242196

Hydrocortisone EP Impurity F

CAS: 152-58-9

Formula: C₂₁H₃₀O₄

Molecular weight: 346.47

Ref: ST-EA-CP-H9006

11-Deoxy Cortisol-d7

Controlled Product

CAS: 152-58-9

Applications Glucocorticoid receptor binding.A representative lots showed approximately 10% d8.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158 (1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),

Formula: C₂₁H₂₃D₇O₄

Color and Shape: Neat

Molecular weight: 353.5

Ref: TR-D232602

11-Deoxy Cortisol

CAS: 152-58-9

Impurity Hydrocortisone EP Impurity F
Applications 11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158(1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),

Formula: C₂₁H₃₀O₄

Color and Shape: Neat

Molecular weight: 346.46

Ref: TR-D232600

11-Deoxy-17-hydroxycorticosterone

Controlled Product

CAS: 152-58-9

11-Deoxycorticosterone (11DOC) is a naturally occurring corticosteroid that has been studied as a potential treatment for cancer. 11DOC is an antagonist of the mineralocorticoid receptor, which regulates sodium and potassium ions in the body. It also inhibits lymphocyte transformation and cell nuclei. The 11DOC-induced tumor regression was found to be due to decreased cortisol concentrations and increased corticosterone concentration in the experimental model. Increased corticosterone concentration led to cell lysis, while decreased cortisol concentration inhibited inflammatory lesion growth. Structural analysis revealed that 11DOC binds to the mineralocorticoid receptor with high affinity, but does not bind with high affinity to the glucocorticoid receptor. This suggests that 11DOC may be used for tumor treatment without negative side effects such as hair loss or increased appetite.

Formula: C₂₁H₃₀O₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 346.46 g/mol

Ref: 3D-FD21045

11-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione)

CAS: 152-58-9

Color and Shape: Neat

Ref: 61-FOR0185.08