CAS 152-58-9
:11-Deoxycortisol
Description:
11-Deoxycortisol, also known as cortodoxone, is a steroid hormone that plays a significant role in the biosynthesis of corticosteroids. It is classified as a glucocorticoid and is produced in the adrenal cortex. The chemical structure of 11-Deoxycortisol features a steroid backbone, characterized by four fused carbon rings, with specific functional groups that contribute to its biological activity. It is a precursor in the synthesis of cortisol, which is crucial for regulating metabolism, immune response, and stress response in the body. The CAS number 152-58-9 uniquely identifies this compound in chemical databases. In terms of solubility, 11-Deoxycortisol is generally lipophilic, allowing it to easily cross cell membranes and exert its effects on target tissues. Its biological activity is mediated through binding to glucocorticoid receptors, influencing gene expression and cellular functions. Due to its role in the endocrine system, alterations in 11-Deoxycortisol levels can be indicative of various health conditions, including adrenal insufficiency or hyperplasia.
Formula:C21H30O4
InChI:InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
InChI key:InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]
Synonyms:- (8R,10R,13S,17R)-17-Hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
- (8Xi,9Xi,10Xi,13Xi,14Xi)-17,21-Dihydroxypregn-4-Ene-3,20-Dione
- 11-Deoxy-17-hydrocorticosterone
- 11-Deoxy-17-hydroxycorticosterone
- 11-Deoxycortisol
- 11-Deoxycortisone
- 11-Deoxyhydrocortisone
- 11-Desoxy-17-hydroxycorticosterone
- 11-Desoxy-17α-hydroxycorticosterone
- 11-Desoxycortisol
- 11-Desoxycortisone
- 11-Desoxyhydrocortisone
- 11-Dioxycortisol
- 17,21-Dihydroxy-4-pregnene-3,20-dione
- 17,21-Dihydroxy-Pregn-4-Ene-3,20-Dione
- 17,21-Dihydroxypregn-4-en-3,20-dione
- 17,21-Dihydroxypregn-4-ene-3,20-dione
- 17,21-Dihydroxyprogesterone
- 17-Hydroxy-11-deoxycorticosterone
- 17alpha,21-Dihydroxypregn-4-ene-3,20-dione
- 17Α,21-Dihydroxypregn-4-Ene-3,20-Dione
- 17α,21-Dihydroxy-4-pregnen-3,20-dion
- 17α,21-Dihydroxy-4-pregnen-3,20-dione
- 17α,21-Dihydroxyprogesterone
- 17α-Hydroxycortexone
- 4-Pregnen-17α,21-diol-3,20-dion
- 4-Pregnen-17α,21-diol-3,20-dione
- 4-Pregnene-11β,17,21-triol-3,20-dione
- 4-Pregnene-17α, 21-diol-3,20-dione
- Compound S
- Corticosterone, 11-deoxy-17-hydroxy-
- Cortifen
- Cortisol, 11-deoxy-
- Cortisol, 11-dioxy-
- Cortodoxon
- Cortodoxona
- Cortodoxone
- Nsc 18317
- Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
- Reichstein S
- Reichstein substance S
- Reichstein's Substanz S
- Reichstein's compound S
- Reichstein's substance S
- Sk&F 3050
- Skf 3050
- Substance S
- cortodoxone (INN)
- Δ4-Pregnene-17α,21-diol-3,20-dione
- Δ<sup>4</sup>-Pregnene-17α,21-diol-3,20-dione
- See more synonyms
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Found 18 products.
Cortexolone
CAS:Formula:C21H30O4Purity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:346.4711-Deoxycortisol (17,21-Dihydroxypregn-4-ene-3,20-dione) 1.0 mg/ml in Methanol
CAS:Color and Shape:ColourlessCortodoxone (17,21-Dihydroxypregn-4-ene-3,20-dione)
CAS:Adrenal cortical hormones and their derivatives nesoiFormula:C21H30O4Color and Shape:White PowderMolecular weight:346.21441Reichsteins substance S
CAS:Formula:C21H30O4Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:346.4617,21-Dihydroxypregn-4-ene-3,20-dione (Reichstein's Substance S)
CAS:Controlled ProductFormula:C21H30O4Color and Shape:NeatMolecular weight:346.46Cortodoxone
CAS:Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.Formula:C21H30O4Purity:99.26% - 99.87%Color and Shape:SolidMolecular weight:346.4611-Deoxy Cortisol
CAS:Impurity Hydrocortisone EP Impurity F
Applications 11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158(1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),Formula:C21H30O4Color and Shape:NeatMolecular weight:346.4611-Deoxy Cortisol-d7
CAS:Controlled ProductApplications Glucocorticoid receptor binding.A representative lots showed approximately 10% d8.
References Gazdar, A., et al.: Cancer Res., 50, 5488, (1990), Bird, I., et al.: Endocrinology, 134, 2468 (1994), Auchus, R., et al.: J. Biol. Chem., 273, 3158 (1998), Dardis, A., et al.: J. Endocrinol., 179, 131 (2003),Formula:C21H23D7O4Color and Shape:NeatMolecular weight:353.517,21-Dihydroxy-pregn-4-ene-3,20-dione
CAS:Formula:C21H30O4Purity:98%Color and Shape:SolidMolecular weight:346.46711-Deoxy-17-hydroxycorticosterone
CAS:Controlled Product11-Deoxycorticosterone (11DOC) is a naturally occurring corticosteroid that has been studied as a potential treatment for cancer. 11DOC is an antagonist of the mineralocorticoid receptor, which regulates sodium and potassium ions in the body. It also inhibits lymphocyte transformation and cell nuclei. The 11DOC-induced tumor regression was found to be due to decreased cortisol concentrations and increased corticosterone concentration in the experimental model. Increased corticosterone concentration led to cell lysis, while decreased cortisol concentration inhibited inflammatory lesion growth. Structural analysis revealed that 11DOC binds to the mineralocorticoid receptor with high affinity, but does not bind with high affinity to the glucocorticoid receptor. This suggests that 11DOC may be used for tumor treatment without negative side effects such as hair loss or increased appetite.Formula:C21H30O4Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:346.46 g/mol
