CAS 152121-30-7

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

Description:

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole, with CAS number 152121-30-7, is a synthetic organic compound characterized by its complex structure, which includes an imidazole ring substituted with various aromatic groups. The presence of a fluorophenyl group contributes to its potential electronic properties, while the hydroxyphenyl moiety may enhance its solubility and reactivity. The pyridyl substituent introduces nitrogen into the structure, which can influence the compound's hydrogen bonding capabilities and overall polarity. This compound may exhibit biological activity, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. Its unique combination of functional groups suggests potential applications in areas such as drug design, where interactions with biological targets are crucial. Additionally, the compound's stability, solubility, and reactivity can be influenced by environmental factors, making it important to consider these characteristics in practical applications. Overall, this compound represents a versatile scaffold for further chemical exploration and potential therapeutic development.

Formula: C₂₀H₁₄FN₃O

InChI: InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChI key: InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N

SMILES: FC1=CC=C(C2=C(N=C(N2)C3=CC=C(O)C=C3)C=4C=CN=CC4)C=C1

Synonyms:

• 2,5-cyclohexadien-1-one, 4-[4-(4-fluorophenyl)-1,3-dihydro-5-(4-pyridinyl)-2H-imidazol-2-ylidene]-
• 4-(4-Fluorophenyl)-2-(4-Hydroxyphenyl)-5-(4-Pyridyl)Imidazole
• 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
• 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
• 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
• 4-[5-(4-Fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
• Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-
• Sb 202190
• Sb202190
• phenol, 4-[5-(4-fluorophenyl)-4-(4-pyridinyl)-1H-imidazol-2-yl]-

SB 202190

CAS: 152121-30-7

Formula: C₂₀H₁₄FN₃O

Purity: >95.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 331.35

Ref: 3B-F0870

4-(4-(4-Fluorophenyl)-5-(Pyridin-4-yl)-1H-Imidazol-2-yl)Phenol

CAS: 152121-30-7

4-(4-(4-Fluorophenyl)-5-(Pyridin-4-yl)-1H-Imidazol-2-yl)Phenol

Formula: C₂₀H₁₄FN₃O

Purity: 98%

Molecular weight: 331.34

Ref: 54-BI12170

SB 202190

CAS: 152121-30-7

SB 202190

Purity: 98%

Molecular weight: 331.34g/mol

Ref: 54-BIS4321

SB 202190

CAS: 152121-30-7

SB 202190

Formula: C₂₀H₁₄FN₃O

Purity: ≥98%

Molecular weight: 331.34

Ref: 54-BUP17555

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

CAS: 152121-30-7

Formula: C₂₀H₁₄FN₃O

Purity: 99%

Color and Shape: Solid

Molecular weight: 331.3431

Ref: IN-DA007YOR

SB 202190

CAS: 152121-30-7

SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.

Formula: C₂₀H₁₄FN₃O

Purity: 98% - 99.94%

Color and Shape: Solid

Molecular weight: 331.3431

Ref: TM-T2301

SB 202190

CAS: 152121-30-7

Formula: C₂₀H₁₄FN₃O

Purity: (HPLC) ≥ 97.0%

Color and Shape: Off-white solid

Molecular weight: 331.35

Ref: 7W-GK2422

SB 202190

CAS: 152121-30-7

4-(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol

Formula: C₂₀H₁₄FN₃O

Purity: 99%

Molecular weight: 331.34

Ref: IN-DG157914

SB 202190

Controlled Product

CAS: 152121-30-7

Applications SB 202190 is a DFG inhibitor used in the treatment of colorectal cancer. It is a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.
References Grossi, V. et al.: Canc. Biol. Ther., 13, 1471 (2012); Chen, Y. et al.: Med. Sci. Mon., 18, BR383 (2012); Horstmann, S. et al.: J. Neurosci. Res., 52, 483 (1998); Zhang, F. et al.: Zhong. Yao. Tong., 18, 512 (2002); Wang, J. et al.: Nanj. Yike Dax. Xue., 29, 840 (2009);

Formula: C₂₀H₁₄FN₃O

Color and Shape: Neat

Molecular weight: 331.34

Ref: TR-S154495

SB 202190

CAS: 152121-30-7

Inhibitor of p38 MAPK kinase

Formula: C₂₀H₁₄FN₃O

Purity: Min. 95%

Molecular weight: 331.34 g/mol

Ref: 3D-FS45614