CAS 152121-47-6

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Description:

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine, with the CAS number 152121-47-6, is a chemical compound characterized by its complex structure that includes both imidazole and pyridine rings. This compound features a fluorophenyl group and a methylsulfinylphenyl substituent, which contribute to its unique chemical properties. The presence of the fluorine atom typically enhances the compound's lipophilicity and may influence its biological activity. The sulfinyl group can also impart distinctive reactivity and solubility characteristics. This compound is likely to exhibit interesting pharmacological properties, making it a candidate for research in medicinal chemistry. Its structural features suggest potential interactions with biological targets, which could be explored in drug development. As with many organic compounds, its stability, solubility, and reactivity will depend on environmental conditions such as pH and temperature. Overall, this compound represents a class of heterocyclic compounds that are of significant interest in both synthetic and medicinal chemistry.

Formula: C₂₁H₁₆FN₃OS

InChI: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChI key: InChIKey=CDMGBJANTYXAIV-UHFFFAOYSA-N

SMILES: FC1=CC=C(C2=C(N=C(N2)C3=CC=C(S(C)=O)C=C3)C=4C=CN=CC4)C=C1

Synonyms:

• 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
• 4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine
• Birb 203580
• Pb 203580
• Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-
• Pyridine, 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]-
• Rwj 64809
• Sb-203580

SB 203580

CAS: 152121-47-6

Formula: C₂₁H₁₆FN₃OS

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 377.44

Ref: 3B-F0864

SB 203580

CAS: 152121-47-6

SB 203580

Formula: C₂₁H₁₆FN₃OS

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: White to off white Solid-Powder

Molecular weight: 377.43464

Ref: 54-BIS0733

4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

CAS: 152121-47-6

Formula: C₂₁H₁₆FN₃OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 377.4346

Ref: IN-DA003K1L

SB 203580

CAS: 152121-47-6

Formula: C₂₁H₁₆FN₃OS

Color and Shape: White To Off-White Solid

Molecular weight: 377.44

Ref: 4Z-S-171001

SB 203580

CAS: 152121-47-6

Formula: C₂₁H₁₆FN₃OS

Purity: ≥ 98.0%

Color and Shape: White to off-white solid

Molecular weight: 377.44

Ref: 7W-GK9716

Adezmapimod

CAS: 152121-47-6

4-(5-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine

Formula: C₂₁H₁₆FN₃OS

Purity: 98%

Molecular weight: 377.43

Ref: IN-DG150875

Adezmapimod

CAS: 152121-47-6

Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.

Formula: C₂₁H₁₆FN₃OS

Purity: 99.42% - 99.93%

Color and Shape: Solid

Molecular weight: 377.43

Ref: TM-T1764

SB-203580

Controlled Product

CAS: 152121-47-6

Stability -200C
Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.
References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),

Formula: C₂₁H₁₆FN₃OS

Color and Shape: Neat

Molecular weight: 377.43

Ref: TR-S154600

SB 203580

CAS: 152121-47-6

Inhibitor of p38 MAPK kinase

Formula: C₂₁H₁₆FN₃OS

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 377.44 g/mol

Ref: 3D-FS27798

Adezmapimod

CAS: 152121-47-6

Ref: BE-RMCS040000

SB-203580

CAS: 152121-47-6

M02481 - SB-203580

Formula: C₂₁H₁₆FN₃OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 377.44

Ref: 10-M02481