CAS 15220-11-8

Potassium 4-methylumbelliferone sulfate

Description:

Potassium 4-methylumbelliferone sulfate, with the CAS number 15220-11-8, is a chemical compound that belongs to the class of sulfonated derivatives of umbelliferone, a naturally occurring coumarin. This compound is characterized by its sulfonate group, which enhances its solubility in water, making it useful in various biochemical applications. It typically exhibits fluorescence properties, which are valuable in analytical chemistry and biological assays, particularly in the detection of enzymes such as sulfatases. The potassium salt form contributes to its stability and solubility in aqueous solutions. Additionally, 4-methylumbelliferone sulfate is often utilized as a substrate in enzymatic reactions and as a fluorescent probe in cellular studies. Its structural features include a methyl group at the 4-position of the umbelliferone backbone, which influences its reactivity and interaction with biological systems. Overall, this compound serves as an important tool in biochemical research, particularly in studies involving enzyme activity and metabolic pathways.

Formula: C₁₀H₈O₆S·K

InChI: InChI=1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);

InChI key: InChIKey=ACUFSQJGNBCODF-UHFFFAOYSA-N

SMILES: CC=1C=2C(=CC(OS(=O)(=O)O)=CC2)OC(=O)C1.[K]

Synonyms:

• Potassium 4-methylumbelliferone sulfate
• 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt (1:1)
• Potassium 4-methylumbelliferyl sulfate
• Coumarin, 7-hydroxy-4-methyl-, hydrogen sulfate potassium salt
• 2H-1-Benzopyran-2-one, 4-methyl-7-(sulfooxy)-, potassium salt

4-Methylumbelliferyl sulfate potassium salt, 98%

CAS: 15220-11-8

Substrate for sulfatase

Formula: C₁₀H₇KO₆S

Purity: 98%

Color and Shape: White, Powder

Molecular weight: 294.32

Ref: 02-J66160

2H-1-BENZOPYRAN-2-ONE,4-METHYL-7-(SULFOOXY)-, POTASSIUM SALT

CAS: 15220-11-8

Formula: C₁₀H₇KO₆S

Purity: 97%

Color and Shape: Solid

Molecular weight: 294.3223

Ref: IN-DA00HXY4

4-Methylumbelliferyl sulphate potassium salt

CAS: 15220-11-8

4-Methylumbelliferyl sulphate potassium salt

Formula: C₁₀H₇O₆S·K

Purity: By hplc: >99% (Typical Value in Batch COA)

Color and Shape: Solid-Powder

Molecular weight: 294.32228

Ref: 54-BIB6119

4-Methylumbelliferyl sulfate potassium salt

CAS: 15220-11-8

Formula: C₁₀H₇KO₆S

Purity: (HPLC) ≥ 98%

Color and Shape: White powder or solid

Molecular weight: 294.30

Ref: 7W-GC5001

4-Methylumbelliferyl Sulfate Potassium Salt

CAS: 15220-11-8

Applications Met-enkephalin analog found in opioid extracts of brain and adrenal chromaffin cells that is an artifact generated by trichloroacetic acid extraction. MUS is used as a fluorimetric substrate for arylsulphatase enzyme. Subsitution of the hydroxyl group of 4-methylumbelliferone (4-methyl-7-hydroxy-coumarin) causes the excitation wavelength of the umbelliferone to shift to shorter values and also brings about a decrease in fluorescence.Fluorescence: max. Abs = 334 mm; max. Em. = 370 mm
References Harinath, B., et al.: J. Neurochem., 18, 245 (1971), Marniemi, J., et al.: Int. J. Biochem., 4, 95 (1973), Bojarova, P., et al.: ChemBioChem., 9, 613 (2008),

Formula: C₁₀H₇O₆S·K

Color and Shape: Neat

Molecular weight: 294.32

Ref: TR-M333100

4-Methylumbelliferyl sulfate, potassium salt

CAS: 15220-11-8

4-Methylumbelliferyl sulfate, potassium salt is a metabolite of 4-methylumbelliferone and has been used as a human serum marker. This molecule is conjugated with glucuronide and p-hydroxybenzoic acid to form the sulfate, glucuronide conjugate. The reaction mechanism of this compound is not known, but it is thought that the metabolism may involve oxidation at the methyl group. The analytical method for this compound can be performed using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). This method can also be used in vitro to test antimicrobial activity against bacteria such as Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa.

Formula: C₁₀H₇KO₆S

Purity: Min. 99.0 Area-%

Molecular weight: 294.33 g/mol

Ref: 3D-M-6200

4-Methylumbelliferyl sulfate potassium salt

CAS: 15220-11-8

4-Methylumbelliferyl sulfate potassium salt serves as a superior fluorogenic substrate in enzyme detection assays. Upon enzymatic hydrolysis, it releases a highly fluorescent 4-methylumbelliferone moiety, enabling real-time analysis and quantification of enzyme activities. This product is ideal for a variety of biological assay applications, including in vitro diagnostics, drug discovery, and research purposes. Its excellent sensitivity, specificity, and performance ensure accurate and consistent results every time.

Formula: C₁₀H₇KO₆S

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 294.32 g/mol

Ref: 3D-EM15697

4-Methylumbelliferyl sulfate potassium salt

CAS: 15220-11-8

M04140 - 4-Methylumbelliferyl sulfate potassium salt

Formula: C₁₀H₇KO₆S

Purity: 97%

Color and Shape: Solid

Molecular weight: 294.32

Ref: 10-M04140

4-Methylumbelliferyl Sulfate Potassium Salt extrapure, 99%

CAS: 15220-11-8

Formula: C₁₀H₇KO₆S

Purity: min. 99%

Color and Shape: White, Powder

Molecular weight: 294.30

Ref: SR-21400

4-Methylumbelliferyl sulfate potassium

CAS: 15220-11-8

4-Methylumbelliferyl sulfate (potassium) is a fluorescent substrate widely used to identify sulfatase activity in biochemical and biomedical research. It features a sulfate group linked to a fluorescent molecule, cleaved by sulfatase enzymes to release a highly fluorescent product detectable via fluorescence microscopy or spectroscopy. This substrate enables precise detection and quantification of sulfatase enzymes across diverse biological samples.

Formula: C₁₀H₇KO₆S

Molecular weight: 294.32

Ref: TM-T85460