CAS 152239-46-8

SB 204741

Description:

SB 204741, with the CAS number 152239-46-8, is a chemical compound that has been studied primarily for its potential applications in pharmacology, particularly as a selective inhibitor of certain protein kinases. This compound is characterized by its specific molecular structure, which allows it to interact with target proteins involved in various cellular processes. SB 204741 has been investigated for its role in modulating signaling pathways, making it of interest in the context of cancer research and other diseases where kinase activity is dysregulated. Its solubility, stability, and bioavailability are important factors that influence its effectiveness as a therapeutic agent. Additionally, studies on SB 204741 have explored its pharmacokinetics and potential side effects, contributing to the understanding of its safety profile. Overall, SB 204741 represents a significant area of research in medicinal chemistry, with ongoing investigations aimed at elucidating its full therapeutic potential and mechanisms of action.

Formula: C₁₄H₁₄N₄OS

InChI: InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)

InChI key: InChIKey=USFUFHFQWXDVMH-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(NC(NC=3SN=C(C)C3)=O)=CC2)C=C1

Synonyms:

• 1-(1-Methyl-1H-indol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
• 1-(1-Methyl-1H-indol-5-yl)-3-(3-methyl-isothiazol-5-yl)-urea
• N-(1-Methyl-1H-indol-5-yl)-N′-(3-methyl-5-isothiazolyl)urea
• N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea
• Sb 204741
• Sb204741
• Urea, N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-

SB 204741

CAS: 152239-46-8

Formula: C₁₄H₁₄N₄OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 286.3522

Ref: IN-DA00AK45

SB 204741

CAS: 152239-46-8

Formula: C₁₄H₁₄N₄OS

Molecular weight: 286.35

Ref: 7W-GK3640

SB 204741

CAS: 152239-46-8

SB 204741

Purity: ≥98%

Molecular weight: 286.35g/mol

Ref: 54-BUP01973

SB 204741

CAS: 152239-46-8

SB 204741 is a selective 5-HT2B antagonist with high affinity and pKi value of 7.1.

Formula: C₁₄H₁₄N₄OS

Purity: 99.83%

Color and Shape: Solid

Molecular weight: 286.35

Ref: TM-T23312

SB 204741

Controlled Product

CAS: 152239-46-8

Applications SB 204741 is a potent, selective SR-2B antagonist.
References West, J. D., et al.: PLoS One, 11, 0148657 (2016)

Formula: C₁₄H₁₄N₄OS

Color and Shape: Neat

Molecular weight: 286.35

Ref: TR-S155025

SB 204741

CAS: 152239-46-8

SB 204741 is a drug that blocks the action of serotonin receptors. It is used in the treatment of autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus. SB 204741 has been shown to reduce levels of cytosolic calcium, which may be due to its inhibition of phospholipase C. This drug also inhibits the polymerase chain reaction and slows cardiac muscle cell growth. In addition, it inhibits the release of growth factor-β1 from platelets and 5-hydroxytryptamine (5-HT) from synaptosomes in rat brain cells. SB 204741 also has a synergistic effect with detrusor muscle relaxants and potentiates the effects of selective 5-HT2C receptor antagonists on 5-HT2B receptors.

Formula: C₁₄H₁₄N₄OS

Purity: Min. 95%

Molecular weight: 286.35 g/mol

Ref: 3D-CGA23946