CAS 152459-95-5: Imatinib

Description: Imatinib, with the CAS number 152459-95-5, is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain cancers, notably chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It functions by selectively inhibiting the BCR-ABL fusion protein, which is a product of a chromosomal translocation commonly associated with CML, as well as other tyrosine kinases involved in cell proliferation and survival. Imatinib is characterized by its chemical formula C29H31N7O2, and it has a molecular weight of approximately 493.6 g/mol. The compound is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good bioavailability and a long half-life, which allows for once-daily dosing. Imatinib's effectiveness is often monitored through molecular response, and it has significantly improved the prognosis for patients with specific malignancies. However, resistance can develop, necessitating ongoing research into combination therapies and second-generation inhibitors.

Formula: C₂₉H₃₁N₇O

InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

InChI key: InChIKey=KTUFNOKKBVMGRW-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=C(C(=C1)NC=2N=CC=C(N2)C3=CN=CC=C3)C)C4=CC=C(C=C4)CN5CCN(C)CC5

Synonyms:

• Imatinib
• CGP 57148
• 4-(4-Methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
• 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate (1:1)
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
• 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
• 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
• AKOS 91378
• IMA-3
• IMATINIB-D3
• Imatinib Base

Imatinib

CAS: 152459-95-5220127-57-1

• Formula: C₂₉H₃₁N₇O
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow to Light orange powder to crystal
• Molecular weight: 493.62

Imatinib Mesylate

CAS: 152459-95-5220127-57-1

• Formula: C₂₉H₃₁N₇O·CH₄O₃S
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 589.72

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide

CAS: 152459-95-5

• Formula: C₂₉H₃₁N₇O
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 493.6027

Imatinib

CAS: 152459-95-5

• Purity: ≥98%
• Molecular weight: 493.6g/mol

Imatinib

CAS: 152459-95-5

• Formula: C₂₉H₃₁N₇O
• Molecular weight: 493.60

Imatinib

CAS: 152459-95-5

• Formula: C₂₉H₃₁N₇O
• Color and Shape: White To Off-White Solid
• Molecular weight: 493.62

Imatinib

CAS: 152459-95-5

• Formula: C₂₉H₃₁N₇O
• Color and Shape: Neat
• Molecular weight: 493.60

Imatinib

CAS: 152459-95-5

• Formula: C₂₉H₃₁N₇O
• Color and Shape: Neat
• Molecular weight: 493.60

Imatinib

CAS: 152459-95-5

Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities …

• Formula: C₂₉H₃₁N₇O
• Purity: 100% - 99.94%
• Color and Shape: Off White Powder
• Molecular weight: 493.6

Imatinib

CAS: 152459-95-5

• Formula: C₂₉H₃₁N₇O
• Purity: >99%
• Color and Shape: off-white to beige solid
• Molecular weight: 493.60g/mol

ADBICA N-(4-Hydroxypentyl) Metabolite

CAS: 152459-95-5

• Formula: C₂₀H₂₉N₃O₃
• Molecular weight: 359.47

Imatinib

CAS: 152459-95-5

Applications Imatinib is an inhibitor of multiple tyrosine kinases. It is a COVID19-related research product.

• Formula: C₂₉H₃₁N₇O
• Color and Shape: Neat
• Molecular weight: 493.60

Imatinib base

CAS: 152459-95-5

BCR-ABL1 kinase inhibitor; neoadjuvant.

• Formula: C₂₉H₃₁N₇O
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 493.6 g/mol

Imatinib base - Bio-X ™

CAS: 152459-95-5

Imatinib is a tyrosine kinase inhibitor that is used in the treatment of various leukemias …

• Formula: C₂₉H₃₁N₇O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 493.6 g/mol