CAS 152459-95-5

Imatinib

Description:

Imatinib, with the CAS number 152459-95-5, is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain cancers, notably chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It functions by selectively inhibiting the BCR-ABL fusion protein, which is a product of a chromosomal translocation commonly associated with CML, as well as other tyrosine kinases involved in cell proliferation and survival. Imatinib is characterized by its chemical formula C29H31N7O2, and it has a molecular weight of approximately 493.6 g/mol. The compound is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good bioavailability and a long half-life, which allows for once-daily dosing. Imatinib's effectiveness is often monitored through molecular response, and it has significantly improved the prognosis for patients with specific malignancies. However, resistance can develop, necessitating ongoing research into combination therapies and second-generation inhibitors.

Formula: C₂₉H₃₁N₇O

InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

InChI key: InChIKey=KTUFNOKKBVMGRW-UHFFFAOYSA-N

SMILES: N(C=1N=C(C=CN1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(C)CC5)C=C4)=CC=C3C

Synonyms:

• Imatinib
• CGP 57148
• 4-(4-Methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
• 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate (1:1)
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
• 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
• 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
• AKOS 91378
• IMA-3
• IMATINIB-D3
• Imatinib Base

Imatinib

CAS: 152459-95-5, 220127-57-1

Formula: C₂₉H₃₁N₇O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 493.62

Ref: 3B-I0906

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide

CAS: 152459-95-5

Formula: C₂₉H₃₁N₇O

Purity: 98%

Color and Shape: Solid

Molecular weight: 493.6027

Ref: IN-DA00350H

Imatinib

CAS: 152459-95-5

Formula: C₂₉H₃₁N₇O

Molecular weight: 493.60

Ref: 7W-GP0221

Imatinib

CAS: 152459-95-5

Formula: C₂₉H₃₁N₇O

Color and Shape: White To Off-White Solid

Molecular weight: 493.62

Ref: 4Z-I-091

Imatinib

CAS: 152459-95-5

Imatinib

Purity: ≥98%

Molecular weight: 493.6g/mol

Ref: 54-BUP17106

Imatinib Mesylate

CAS: 152459-95-5, 220127-57-1

Formula: C₂₉H₃₁N₇O·CH₄O₃S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 589.72

Ref: 3B-I0936

Imatinib

Controlled Product

CAS: 152459-95-5

Formula: C₂₉H₃₁N₇O

Color and Shape: Neat

Molecular weight: 493.60

Ref: 86-MM1196.00

Imatinib

Controlled Product

CAS: 152459-95-5

Formula: C₂₉H₃₁N₇O

Color and Shape: Neat

Molecular weight: 493.60

Ref: 04-C14279800

ADBICA N-(4-Hydroxypentyl) Metabolite

CAS: 152459-95-5

Formula: C₂₀H₂₉N₃O₃

Molecular weight: 359.47

Ref: 4Z-I-091007

Imatinib

CAS: 152459-95-5

Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit

Formula: C₂₉H₃₁N₇O

Purity: 99.42% - 99.94%

Color and Shape: Off White Powder

Molecular weight: 493.6

Ref: TM-T6230

Imatinib

CAS: 152459-95-5

Imatinib

Formula: C₂₉H₃₁N₇O

Purity: >99%

Color and Shape: off-white to beige solid

Molecular weight: 493.60g/mol

Ref: 54-BIFK0025

Imatinib

Controlled Product

CAS: 152459-95-5

Applications Imatinib is an inhibitor of multiple tyrosine kinases. It is a COVID19-related research product.

Formula: C₂₉H₃₁N₇O

Color and Shape: Neat

Molecular weight: 493.60

Ref: TR-I268023

Imatinib base - Bio-X ™

CAS: 152459-95-5

Imatinib is a tyrosine kinase inhibitor that is used in the treatment of various leukemias and gastrointestinal stromal tumors. This drug inhibits the BCR-ABL tyrosine kinase. It is suggested that Imatinib also inhibits other tyrosine kinases such as PDGF, SCF and c-Kit.

Formula: C₂₉H₃₁N₇O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 493.6 g/mol

Ref: 3D-BI164570

Imatinib base

CAS: 152459-95-5

BCR-ABL1 kinase inhibitor; neoadjuvant.

Formula: C₂₉H₃₁N₇O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 493.6 g/mol

Ref: 3D-FM10813