CAS 152459-95-5
:Imatinib
Description:
Imatinib, with the CAS number 152459-95-5, is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain cancers, notably chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It functions by selectively inhibiting the BCR-ABL fusion protein, which is a product of a chromosomal translocation commonly associated with CML, as well as other tyrosine kinases involved in cell proliferation and survival. Imatinib is characterized by its chemical formula C29H31N7O2, and it has a molecular weight of approximately 493.6 g/mol. The compound is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good bioavailability and a long half-life, which allows for once-daily dosing. Imatinib's effectiveness is often monitored through molecular response, and it has significantly improved the prognosis for patients with specific malignancies. However, resistance can develop, necessitating ongoing research into combination therapies and second-generation inhibitors.
Formula:C29H31N7O
InChI:InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
InChI key:InChIKey=KTUFNOKKBVMGRW-UHFFFAOYSA-N
SMILES:N(C=1N=C(C=CN1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(C)CC5)C=C4)=CC=C3C
Synonyms:- Imatinib
- CGP 57148
- 4-(4-Methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
- 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate (1:1)
- Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
- 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
- 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
- AKOS 91378
- IMA-3
- IMATINIB-D3
- Imatinib Base
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Imatinib
CAS:Formula:C29H31N7OPurity:>98.0%(HPLC)Color and Shape:White to Light yellow to Light orange powder to crystalMolecular weight:493.624-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
CAS:Formula:C29H31N7OPurity:98%Color and Shape:SolidMolecular weight:493.6027Imatinib
CAS:Controlled ProductApplications Imatinib is an inhibitor of multiple tyrosine kinases. It is a COVID19-related research product.
Formula:C29H31N7OColor and Shape:NeatMolecular weight:493.6Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormula:C29H31N7OPurity:99.42% - 99.95%Color and Shape:SolidMolecular weight:493.6027Imatinib base
CAS:BCR-ABL1 kinase inhibitor; neoadjuvant.
Formula:C29H31N7OPurity:Min. 95%Color and Shape:White PowderMolecular weight:493.6 g/molImatinib base - Bio-X ™
CAS:Imatinib is a tyrosine kinase inhibitor that is used in the treatment of various leukemias and gastrointestinal stromal tumors. This drug inhibits the BCR-ABL tyrosine kinase. It is suggested that Imatinib also inhibits other tyrosine kinases such as PDGF, SCF and c-Kit.Formula:C29H31N7OPurity:Min. 95%Color and Shape:PowderMolecular weight:493.6 g/mol
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