CAS 152520-56-4
:Nebivolol hydrochloride
Description:
Nebivolol hydrochloride is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to lower blood pressure by reducing heart rate and myocardial contractility, thereby decreasing cardiac output. Nebivolol is unique among beta-blockers due to its vasodilatory properties, which are attributed to its ability to stimulate the release of nitric oxide, leading to improved endothelial function. The substance is typically administered orally and is well-absorbed, with a favorable pharmacokinetic profile that includes a long half-life, allowing for once-daily dosing. Nebivolol hydrochloride is generally well-tolerated, with a side effect profile that may include headache, fatigue, and gastrointestinal disturbances. Its chemical structure includes a chiral center, resulting in different pharmacological effects between its enantiomers. Overall, Nebivolol hydrochloride represents a modern approach to managing cardiovascular conditions, combining efficacy with a relatively favorable safety profile.
Formula:C22H25F2NO4·ClH
InChI:InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/s2
InChI key:InChIKey=JWEXHQAEWHKGCW-NJEBDULONA-N
SMILES:[C@@H](CNC[C@H](O)[C@]1(OC=2C(CC1)=CC(F)=CC2)[H])(O)[C@@]3(OC=4C(CC3)=CC(F)=CC4)[H].Cl
Synonyms:- 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] hydrochloride
- 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride (1:1), (αR,α′R,2R,2′S)-rel-
- 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, (αR,α′R,2R,2′S)-rel-
- 2H-1-Benzopyran-2-methanol, α,α′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, hydrochloride, [2R*[R*[R*(S*)]]]-
- Lobivon
- Nebicard
- Nebilet
- Nebilox
- Nebivolol hcl
- Nebivololhydrochloride(Subjecttopatentfree)
- Nodon
- R 067555
- R-67555
- Rac Nebivolol, Hydrochloride
- a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
- a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
- NEBIVOLOL HC
- Nebivolol (Bystolic)
- alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
- D06622
- a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
- Nebivolol hydrochloride (usan)
- Nebivolol hydrochloride, >=98%
- (aR,a,2R,2)-rel-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
- (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
- rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
- Nebivolol hydrochloride
- Bystolic
- Narbivolol
- See more synonyms
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Found 16 products.
Nebivolol Hydrochloride
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormula:C22H25F2NO4·HClColor and Shape:White Off-White PowderMolecular weight:441.15184Nebivolol Hydrochloride
CAS:Formula:C22H26ClF2NO4Purity:97%Color and Shape:SolidMolecular weight:441.8959Nebivolol hydrochloride
CAS:<p>Nebivolol hydrochloride is a beta-1 blocker and vasodilator treating hypertension and heart failure in the elderly.</p>Formula:C22H25F2NO4·HClPurity:99.77% - >99.99%Color and Shape:White To Off-White PowderMolecular weight:441.90Nebivolol hydrochloride
CAS:Formula:C22H25F2NO4·HClPurity:≥ 98.0% (anhydrous basis)Color and Shape:White to off-white crystalline powderMolecular weight:441.90Nebivolol HCl
CAS:Formula:C22H25F2NO4·HClColor and Shape:White To Off-White SolidMolecular weight:405.45 36.46Nebivolol Hydrochloride
CAS:Controlled ProductFormula:C22H25F2NO4·ClHColor and Shape:NeatMolecular weight:441.90Nebivolol Hydrochloride
CAS:Formula:C22H25F2NO4·HClPurity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:441.90Nebivolol Hydrochloride
CAS:<p>Applications Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988), De Cree, J., et al.: Angiology, 41, 95 (1990);<br></p>Formula:C22H25F2NO4·ClHColor and Shape:WhiteMolecular weight:441.90Nebivolol HCl - Bio-X ™
CAS:Controlled Product<p>Nebivolol is a beta-blocker that is used to treat high blood pressure. It is also used in the treatment of angina, to decrease the heart rate and contractile force. Nebivolol has weak beta-2 adrenergic receptor antagonist action but is a highly selective beta-1 adrenergic receptor antagonist. Nebivolol's ability to block beta-1 adrenergic receptors results in a reduction in myocardial contractility, systolic and diastolic blood pressure, resting heart rate, and workout heart rate.</p>Formula:C22H25F2NO4·HClPurity:(%) Min. 95%Color and Shape:White/Off-White SolidMolecular weight:441.9 g/molNebivolol hydrochloride
CAS:Controlled ProductNebivolol HCl is a beta-blocker that is used to treat high blood pressure and heart failure. It is a prodrug that is metabolized in vivo to its active form, nebivolol. Nebivolol HCl has a low bioavailability of about 5%, which may be due to the presence of excipients or the formation of solid dispersions with other ingredients in the formulation. Nebivolol HCl also interacts with many drugs that are metabolized by CYP2D6, CYP3A4, and CYP1A2 enzymes, such as metoprolol succinate, sodium citrate, and hydrochloric acid. This drug also has an adverse effect on geriatric patients because it can cause dizziness due to orthostatic hypotension.Formula:C22H25F2NO4•HClPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:441.9 g/mol
