CAS 15291-75-5

Ginkgolide A

Description:

Ginkgolide A is a natural compound derived from the leaves of the Ginkgo biloba tree, known for its potential health benefits and medicinal properties. It belongs to a class of compounds called terpenoids, specifically a type of diterpene lactone. Ginkgolide A is characterized by its unique bicyclic structure, which contributes to its biological activity. It exhibits various pharmacological effects, including neuroprotective, anti-inflammatory, and antioxidant properties, making it of interest in the study of neurodegenerative diseases and cognitive enhancement. Additionally, Ginkgolide A has been investigated for its ability to inhibit platelet-activating factor (PAF), which plays a role in inflammation and thrombosis. The compound is typically found in herbal supplements and extracts derived from Ginkgo biloba, and its safety profile has been evaluated in various studies. However, like many herbal products, it may interact with other medications, so caution is advised when used in conjunction with anticoagulants or antiplatelet drugs. Overall, Ginkgolide A represents a significant area of research in phytochemistry and pharmacology.

Formula: C₂₀H₂₄O₉

InChI: InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18?,19-,20?/m1/s1

InChI key: InChIKey=FPUXKXIZEIDQKW-IKIFPUOBSA-N

SMILES: O[C@@]12C34[C@]5(C6([C@](O3)(OC(=O)[C@@H]6O)[H])[C@H](C(C)(C)C)C[C@]5(OC4=O)[H])C[C@@]1(OC(=O)[C@H]2C)[H]

Synonyms:

• (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
• (1R,3aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• (3aR,4aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R-(1alpha,3beta,3aS*,4beta,6aalpha,7aalpha,7balpha,8alpha,10aalpha,11 aS*))-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-
• 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
• Bilobalide A
• Bn 52020
• [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 408.40

Ref: 3B-G0521

Ginkgolide A

CAS: 15291-75-5

Platelet-Activating Factor (PAF) antagonist

Formula: C₂₀H₂₄O₉

Molecular weight: 408.41

Ref: 02-J62384

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₂₀H₂₄O₉

Purity: (HPLC) ≥98%

Color and Shape: Powder

Molecular weight: 408.41

Ref: 11-3728S

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 408.3992

Ref: IN-DA003839

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Purity: 97%

Molecular weight: 408.4g/mol

Ref: 54-OR1024130

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A

Purity: ≥98%

Molecular weight: 408.4g/mol

Ref: 54-BUP06903

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a platelet-activating factor antagonist, it can inhibit the neurotoxicity of prions or amyloid-beta1-42, may be relevant treatments for prion or Alzheimer's diseases.Ginkgolide A has neuroprotective, and anxiolytic-like effects, it is widely used for the treatment of cardiovascular diseases and diabetic vascular complications, which might be achieved through regulating the STAT3-mediated pathway.

Formula: C₂₀H₂₄O₉

Purity: 95%~99%

Molecular weight: 408.403

Ref: BP-BP0646

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A (BN-52020), from Ginkgo biloba leaves, is an active PAF antagonist with potential in treating inflammation and immune disorders.

Formula: C₂₀H₂₄O₉

Purity: 98.76% - 99.81%

Color and Shape: White Powder

Molecular weight: 408.4

Ref: TM-T2749

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Molecular weight: 408.40

Ref: 4Z-G-176003

Ginkgolide A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Purity: (HPLC) ≥ 98.0%

Color and Shape: Off-white powder

Molecular weight: 408.41

Ref: 7W-GP9109

Ginkgolide a

CAS: 15291-75-5

Lactone

Formula: C₂₀H₂₄O₉

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 408.41

Ref: 5G-89204

Ginkgolide A

Controlled Product

CAS: 15291-75-5

Applications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)

Formula: C₂₀H₂₄O₉

Color and Shape: Neat

Molecular weight: 408.40

Ref: TR-G387425

Ginkgolide A

CAS: 15291-75-5

Ginkgolide A is a terpenoid lactone, which is a diterpene known for its presence in the leaves of the Ginkgo biloba tree. As a bioactive compound, it is naturally sourced from this ancient plant, which has been utilized in traditional medicine for centuries. Ginkgolide A acts primarily as an antagonist of platelet-activating factor (PAF), thereby influencing a range of physiological processes. Its modulatory effects on neurotransmission and vascular function arise from its ability to inhibit PAF binding to its receptor, reducing platelet aggregation and improving microcirculatory flow.

Formula: C₂₀H₂₄O₉

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 408.4 g/mol

Ref: 3D-FG10335

Ginkgolide Impurity A

CAS: 15291-75-5

Formula: C₂₀H₂₄O₉

Molecular weight: 408.40

Ref: ST-EA-CP-G15001