CAS 15291-75-5
:Ginkgolide A
Description:
Ginkgolide A is a natural compound derived from the leaves of the Ginkgo biloba tree, known for its potential health benefits and medicinal properties. It belongs to a class of compounds called terpenoids, specifically a type of diterpene lactone. Ginkgolide A is characterized by its unique bicyclic structure, which contributes to its biological activity. It exhibits various pharmacological effects, including neuroprotective, anti-inflammatory, and antioxidant properties, making it of interest in the study of neurodegenerative diseases and cognitive enhancement. Additionally, Ginkgolide A has been investigated for its ability to inhibit platelet-activating factor (PAF), which plays a role in inflammation and thrombosis. The compound is typically found in herbal supplements and extracts derived from Ginkgo biloba, and its safety profile has been evaluated in various studies. However, like many herbal products, it may interact with other medications, so caution is advised when used in conjunction with anticoagulants or antiplatelet drugs. Overall, Ginkgolide A represents a significant area of research in phytochemistry and pharmacology.
Formula:C20H24O9
InChI:InChI=1S/C20H24O9/c1-7-12(22)26-10-6-17-9-5-8(16(2,3)4)18(17)11(21)13(23)28-15(18)29-20(17,14(24)27-9)19(7,10)25/h7-11,15,21,25H,5-6H2,1-4H3/t7-,8+,9-,10+,11+,15+,17-,18?,19-,20?/m1/s1
InChI key:InChIKey=FPUXKXIZEIDQKW-IKIFPUOBSA-N
SMILES:O[C@@]12C34[C@]5(C6([C@](O3)(OC(=O)[C@@H]6O)[H])[C@H](C(C)(C)C)C[C@]5(OC4=O)[H])C[C@@]1(OC(=O)[C@H]2C)[H]
Synonyms:- (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
- (1R,3aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
- (3aR,4aR,4bR,5S,7aS,9R,11S)-11-tert-butyl-1,4b-dihydroxy-5-methyltetrahydro-4bH,9H-9,4a-(epoxymethano)cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H,5H)-trione
- 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
- 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R-(1alpha,3beta,3aS*,4beta,6aalpha,7aalpha,7balpha,8alpha,10aalpha,11 aS*))-
- 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta(c)furo(2,3-b)furo(3',2':3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
- 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-
- 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-
- 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-tert-butylhexahydro-4,7b-dihydroxy-8-methyl-
- Bilobalide A
- Bn 52020
- [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11aS*)]-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
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Ginkgolide A
CAS:Formula:C20H24O9Purity:>98.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:408.40Ginkgolide A
CAS:Ginkgolide A is a platelet-activating factor antagonist, it can inhibit the neurotoxicity of prions or amyloid-beta1-42, may be relevant treatments for prion or Alzheimer's diseases.Ginkgolide A has neuroprotective, and anxiolytic-like effects, it is widely used for the treatment of cardiovascular diseases and diabetic vascular complications, which might be achieved through regulating the STAT3-mediated pathway.Formula:C20H24O9Purity:95%~99%Molecular weight:408.403Ginkgolide A (Standard)
CAS:Ginkgolide A (Standard) is a reference standard for research and analysis in studies involving Ginkgolide A. Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule that is isolated from the leaves of the Ginkgo biloba tree. Shows potential in a wide variety of inflammatory and immunological disorders.Formula:C20H24O9Molecular weight:408.3992Ginkgolide A
CAS:Ginkgolide A analytical standard provided with w/w absolute assay, to be used for quantitative titration.Formula:C20H24O9Purity:(HPLC) ≥98%Color and Shape:PowderMolecular weight:408.41Ginkgolide A
CAS:Controlled ProductApplications Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.
References Korth, R., et al.: Eur. J. Pharmacol., 152, 101 (1988), Braquet, P., et al.: Med. Res. Rev., 11, 295 (1991), van Beek, T.A., et al.: Bioorg. Med. Chem., 13, 5001 (2005)Formula:C20H24O9Color and Shape:NeatMolecular weight:408.4Ginkgolide A
CAS:Formula:C20H24O9Purity:(HPLC) ≥ 98.0%Color and Shape:Off-white powderMolecular weight:408.41Ginkgolide A
CAS:Ginkgolide A (BN-52020), from Ginkgo biloba leaves, is an active PAF antagonist with potential in treating inflammation and immune disorders.Formula:C20H24O9Purity:98.76% - 99.81%Color and Shape:White SolidMolecular weight:408.3992Ginkgolide A
CAS:LactoneFormula:C20H24O9Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:408.41Ginkgolide A
CAS:Ginkgolide A is a terpenoid lactone, which is a diterpene known for its presence in the leaves of the Ginkgo biloba tree. As a bioactive compound, it is naturally sourced from this ancient plant, which has been utilized in traditional medicine for centuries. Ginkgolide A acts primarily as an antagonist of platelet-activating factor (PAF), thereby influencing a range of physiological processes. Its modulatory effects on neurotransmission and vascular function arise from its ability to inhibit PAF binding to its receptor, reducing platelet aggregation and improving microcirculatory flow.Formula:C20H24O9Purity:Min. 95%Color and Shape:White PowderMolecular weight:408.4 g/mol
