CAS 1532533-67-7

Umbralisib

CAS: 1532533-67-7

(S)-2-(1-(4-Amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Formula: C₃₁H₂₄F₃N₅O₃

Purity: 99% (HPLC)

Molecular weight: 571.55

Ref: IN-DG303424

Umbralisib

CAS: 1532533-67-7

Umbralisib

Formula: C₃₁H₂₄F₃N₅O₃

Purity: ≥98%

Molecular weight: 571.55

Ref: 54-BUP04466

Umbralisib

CAS: 1532533-67-7

Umbralisib (TGR 1202) is a PI3Kδ inhibitor.

Formula: C₃₁H₂₄F₃N₅O₃

Purity: 99.56% - 99.56%

Color and Shape: White Solid

Molecular weight: 571.55

Ref: TM-T4976

TGR 1202

CAS: 1532533-67-7

TGR 1202 is a monoclonal antibody that modulates the immune system. It has been shown to inhibit the activation of PI3K-δ, which plays a role in T-cell lymphomas and hematologic response. TGR 1202 also has minimal toxicity, with no adverse effects seen at doses up to 1.5 mg/kg in vivo. TGR 1202 binds to receptors on lymphocytes, leading to cell apoptosis and inhibition of proliferation. The drug is active against monoclonal antibody-resistant leukemic mice and has synergistic effects when used with other drugs like ibrutinib or lenalidomide. Pharmacokinetic properties have been studied in mice, dogs, and monkeys. TGR 1202 shows good pharmacokinetics in vivo, with a half-life of about 10 hours in mice, dogs, and monkeys.

Formula: C₃₁H₂₄F₃N₅O₃

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 571.55 g/mol

Ref: 3D-FT171036

TGR-1202

CAS: 1532533-67-7

Formula: C₃₁H₂₄F₃N₅O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 571.5492

Ref: IN-DA00ABLW