CAS 153381-68-1

7-Epi-docetaxel

Description:

7-Epi-docetaxel is a semi-synthetic derivative of the natural product taxol (paclitaxel), which is used primarily in cancer therapy. It is characterized by its ability to inhibit microtubule depolymerization, thereby disrupting the normal function of the mitotic spindle during cell division, leading to apoptosis in rapidly dividing cancer cells. The chemical structure of 7-Epi-docetaxel includes a taxane core with specific modifications that enhance its pharmacological properties, such as improved solubility and bioavailability compared to its parent compound. This compound exhibits a broad spectrum of antitumor activity against various malignancies, including breast, lung, and ovarian cancers. Its mechanism of action involves binding to the β-subunit of tubulin, stabilizing microtubules, and preventing their disassembly. Additionally, 7-Epi-docetaxel has been studied for its potential to overcome resistance mechanisms that limit the effectiveness of traditional taxanes. As with many chemotherapeutic agents, its use is associated with a range of side effects, necessitating careful management during treatment.

Formula: C₄₃H₅₃NO₁₄

Synonyms:

• (2b,5b,7a,10b,13a)-4-Acetoxy-13-(((2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl)oxy)-1,7,10-trihydroxy- 9-oxo-5,20-epoxytax-11-en-2-yl Benzoate
• 7-Epidocetaxel
• 7-Epitaxotere
• Docetaxel Impurity C
• 7-Epi-docetaxel (Docetaxel Impurity C)
• Docetaxel Impurity 3(Docetaxel EP Impurity C)
• Docetaxel Trihydrate Impurity C
• 7-Methicetaxel
• 5β,20-epoxy-1,7α,10β-trihydroxy-9-oxotax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (7-epi-docetaxel),
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS...
• Docetaxel EP Impurity C/ 4-Epi-Docetaxel (7-epi-Docetaxel/7-Epi-Taxotere)
• Docetaxel EP Impurity C
• Docetaxel Trihydrate EP Impurity C
• Docetaxel Anhydrous Impurity C
• Docetaxel imp-C
• 4-epi-Docetaxel
• Docetaxel Anhydrous EP Impurity C

4-Epi Docetaxel

CAS: 153381-68-1

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₄₃H₅₃NO₁₄

Color and Shape: White Powder

Molecular weight: 807.34661

Ref: 45-1A06240

7-Epi-docetaxel (Docetaxel Impurity C)

CAS: 153381-68-1

Formula: C₄₃H₅₃NO₁₄

Purity: 99.49%

Color and Shape: Solid

Molecular weight: 807.8792

Ref: IN-DA00ABI7

Cyclo(-RGDyC)acetate

CAS: 153381-68-1

Cyclo(-RGDyC)acetate

Purity: ≥95%

Ref: 54-BUP20465

Docetaxel EP Impurity C (7-epi-Docetaxel)

CAS: 153381-68-1

Formula: C₄₃H₅₃NO₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 807.89

Ref: 4Z-D-193

7-Epi-docetaxel

CAS: 153381-68-1

7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.

Formula: C₄₃H₅₃NO₁₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 807.88

Ref: TM-TQ0247

7-epi-Docetaxel

CAS: 153381-68-1

Color and Shape: White

Ref: 86-MM3396.07

7-Epi-docetaxel

CAS: 153381-68-1

Molecular weight: 807.89

Ref: 10-F987615

Docetaxel EP Impurity C

CAS: 153381-68-1

Formula: C₄₃H₅₃NO₁₄

Molecular weight: 807.89

Ref: ST-EA-CP-D32003

7-Epi Docetaxel

Controlled Product

CAS: 153381-68-1

Impurity Docetaxel EP Impurity C
Applications 7-Epi Docetaxel (Docetaxel EP Impurity C) is an isomer of Docetaxel (D494420). Docetaxel injection impurity C.
References Hanna, I., et al.: Cancer Res., 60, 3440 (2000), Bournique, B., et al.: Br. J. Clin. Pharmacol., 52, 53 (2001), McFadyen, M., et al.: Biochem. Pharmacol., 62, 207 (2001), Vasu Dev, R., et al.: J. Pharm. Biomed. Anal., 40, 614 (2006),

Formula: C₄₃H₅₃NO₁₄

Color and Shape: White

Molecular weight: 807.88

Ref: TR-E585300