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CAS 153381-68-1

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7-Epi-docetaxel

Description:
7-Epi-docetaxel is a semi-synthetic derivative of the natural product taxol (paclitaxel), which is used primarily in cancer therapy. It is characterized by its ability to inhibit microtubule depolymerization, thereby disrupting the normal function of the mitotic spindle during cell division, leading to apoptosis in rapidly dividing cancer cells. The chemical structure of 7-Epi-docetaxel includes a taxane core with specific modifications that enhance its pharmacological properties, such as improved solubility and bioavailability compared to its parent compound. This compound exhibits a broad spectrum of antitumor activity against various malignancies, including breast, lung, and ovarian cancers. Its mechanism of action involves binding to the β-subunit of tubulin, stabilizing microtubules, and preventing their disassembly. Additionally, 7-Epi-docetaxel has been studied for its potential to overcome resistance mechanisms that limit the effectiveness of traditional taxanes. As with many chemotherapeutic agents, its use is associated with a range of side effects, necessitating careful management during treatment.
Formula:C43H53NO14
Synonyms:
  • (2b,5b,7a,10b,13a)-4-Acetoxy-13-(((2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl)oxy)-1,7,10-trihydroxy- 9-oxo-5,20-epoxytax-11-en-2-yl Benzoate
  • 7-Epidocetaxel
  • 7-Epitaxotere
  • Docetaxel Impurity C
  • 7-Epi-docetaxel (Docetaxel Impurity C)
  • Docetaxel Impurity 3(Docetaxel EP Impurity C)
  • Docetaxel Trihydrate Impurity C
  • 7-Methicetaxel
  • 5β,20-epoxy-1,7α,10β-trihydroxy-9-oxotax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (7-epi-docetaxel),
  • Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS...
  • See more synonyms
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Found 9 products.