CAS 154-21-2

Lincomycin

Description:

Lincomycin is an antibiotic that belongs to the lincosamide class, primarily used to treat bacterial infections, particularly those caused by anaerobic bacteria and certain gram-positive organisms. It is derived from the bacterium *Streptomyces lincolnensis*. Lincomycin is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the growth and reproduction of bacteria. The substance is typically administered via injection or orally, depending on the severity of the infection. Lincomycin is known for its effectiveness against infections such as osteomyelitis, pneumonia, and skin infections. However, it may cause side effects, including gastrointestinal disturbances and, in rare cases, severe allergic reactions. Resistance to lincomycin can occur, necessitating careful consideration of its use in clinical settings. Its chemical structure includes a thioether and an amino acid component, contributing to its biological activity. As with all antibiotics, appropriate use is crucial to minimize the development of resistance and ensure therapeutic efficacy.

Formula: C₁₈H₃₄N₂O₆S

InChI: InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1

InChI key: InChIKey=OJMMVQQUTAEWLP-KIDUDLJLSA-N

SMILES: [C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)([C@@H](C)O)[C@]2(O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[H]

Synonyms:

• <span class="text-smallcaps">D</smallcap>-erythro-<smallcap>D</smallcap>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-<smallcap>L</span>-2-pyrrolidinecarboxamido)-1-thio-, trans-α-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• <span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
• Cillimycin
• D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-α-
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
• D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amin o]-1-thio-
• Jiemycin
• Lincolcina
• Lincolnensin
• Lincomicina
• Lincomix
• Lincomycin
• Lincomycin A
• Lincomycine
• Medoglycine
• Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-<span class="text-smallcaps">D</smallcap>-erythro-α-<smallcap>D</span>-galacto-octopyranoside
• Nsc 70731
• U 10,149A
• U 10149
• Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside

Lincomycin Hydrochloride Monohydrate

CAS: 154-21-2, 7179-49-9, 859-18-7

Formula: C₁₈H₃₄N₂O₆S·HCl·H₂O

Purity: >98.0%(T)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 461.02

Ref: 3B-L0166

Lincomycin

CAS: 154-21-2

Formula: C₁₈H₃₄N₂O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 406.5374

Ref: IN-DA00395H

Lincomycin-13C-d3 (Clindamycin Phosphate EP Impurity A-13C-d3)

CAS: 154-21-2

Formula: C₁₇₁₃CH₃₁D₃N₂O₆S

Molecular weight: 410.55

Ref: 4Z-L-093012

Lincomycin

CAS: 154-21-2

Lincomycin

Purity: ≥98%

Molecular weight: 406.54g/mol

Ref: 54-BUP21071

Lincomycin

CAS: 154-21-2

Ref: 7W-GA8072

Lincomycin

CAS: 154-21-2

Lincomycin (U-10149) is a antibiotic against most susceptible gram-positive and cell wall-less bacteria .

Formula: C₁₈H₃₄N₂O₆S

Purity: 99.77%

Color and Shape: Amorphous Solid Solid

Molecular weight: 406.54

Ref: TM-T1235L

Lincomycin

CAS: 154-21-2

Impurity Clindamycin Phosphate EP Impurity A
Stability Hygroscopic
Applications Lincomycin (Clindamycin Phosphate EP Impurity A) is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.This compound is a contaminant of emerging concern (CECs).
References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),

Formula: C₁₈H₃₄N₂O₆S

Color and Shape: White To Off-White

Molecular weight: 406.54

Ref: TR-L466230

Lincomycin-D3

Controlled Product

CAS: 154-21-2

Stability Hygroscopic
Applications Labelled Lincomycin. An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References Mason, D. J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H. Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994)

Formula: C₁₈H₃₁D₃N₂O₆S

Color and Shape: White To Yellow

Molecular weight: 409.56

Ref: TR-L466202

Lincomycin

CAS: 154-21-2

Inhibitor of protein synthesis; lincosamide

Formula: C₁₈H₃₄N₂O₆S

Purity: Min. 97 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 406.54 g/mol

Ref: 3D-AL76787

Lincomycin

CAS: 154-21-2

Purity: 98%

Molecular weight: 406.5400085

Ref: 10-F608586

Lincomycin-13C,D3

Controlled Product

CAS: 154-21-2

Formula: C₁₇CH₃₁D₃N₂O₆S

Color and Shape: Neat

Molecular weight: 410.55

Ref: TR-L466232

Clindamycin Phosphate EP Impurity A

CAS: 154-21-2

Formula: C₁₈H₃₄N₂O₆S

Molecular weight: 406.54

Ref: ST-EA-CP-C26001