CAS 154-93-8

carmustine

Description:

Carmustine, with the CAS number 154-93-8, is a potent alkylating agent primarily used in cancer chemotherapy. It belongs to the class of nitrosoureas, which are characterized by their ability to cross the blood-brain barrier, making them effective for treating brain tumors and certain other malignancies. Carmustine is a white to off-white crystalline powder that is soluble in organic solvents but has limited solubility in water. Its mechanism of action involves the formation of DNA cross-links, which inhibits DNA replication and transcription, ultimately leading to cell death. Carmustine is typically administered intravenously and can be associated with various side effects, including myelosuppression, nausea, and potential long-term effects such as pulmonary toxicity. Due to its reactivity and potential for causing secondary malignancies, careful handling and monitoring are essential during its use. Overall, carmustine remains a critical component in the treatment regimens for specific cancers, particularly in cases where other therapies may be less effective.

Formula: C₅H₉Cl₂N₃O₂

InChI: InChI=1/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChI key: InChIKey=DLGOEMSEDOSKAD-UHFFFAOYSA-N

SMILES: N(C(NCCCl)=O)(CCCl)N=O

Synonyms:

• 1,3-Bis(2-Chloroethyl)-1-Nitroso-Urea
• 1,3-Bis(2-chlorethyl)-1-nitrosourea
• 1,3-Bis(2-chloroethyl)-1-nitrosourea
• 1,3-Bis(2-chloroethyl)nitrosourea
• 1,3-Bis(β-chloroethyl)-1-nitrosourea
• Bcnu
• Becenum
• Becenun
• BiCNU
• Carmubris
• Carmustin
• Carmustina
• Dti 015
• Fda 0345
• Gliadel
• Gliadel Wafer
• N,N'-Bis(2-chloroethyl)-N-nitrosourea
• Nitrumon
• Nsc 409962
• Sk 27702
• Sri 1720
• Urea, 1,3-bis(2-chloroethyl)-1-nitroso-
• Urea, N,N'-bis(2-chloroethyl)-N'-nitroso-
• 1,3-bis(beta-chloroethyl)-1-nitrosourea
• n,n’-bis(2-chloroethyl)-n-nitroso-ure
• nci-c04773
• bischlorethylnitrosurea
• bis(2-chloroethyl)nitrosourea
• sk27702
• bischloroethylnitrosourea
• 1,3-bis(2-chloroethyl)-1-nitroso-ure
• fda0345

Carmustine

CAS: 154-93-8

Formula: C₅H₉Cl₂N₃O₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 214.05

Ref: 3B-C2634

CARMUSTINE CRS

CAS: 154-93-8

CARMUSTINE CRS

Color and Shape: Powder

Ref: 41-Y0002128

Carmustine

CAS: 154-93-8

Compounds with other nitrogen function, nesoi

Formula: C₅H₉Cl₂N₃O₂

Color and Shape: Light Yellow Powder

Molecular weight: 213.00718

Ref: 45-1096724

1,3-Bis(2-chloroethyl)nitrosourea

CAS: 154-93-8

Formula: C₅H₉Cl₂N₃O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 214.0499

Ref: IN-DA003DHD

Carmustine

CAS: 154-93-8

Formula: C₅H₉Cl₂N₃O₂

Molecular weight: 214.05

Ref: 4Z-C-474001

Carmustine

CAS: 154-93-8

Carmustine

Purity: ≥98%

Molecular weight: 214.05g/mol

Ref: 54-BUP13658

Carmustine

CAS: 154-93-8

Formula: C₅H₉Cl₂N₃O₂

Purity: ≥ 95.0%

Color and Shape: Pale yellow to yellow-orange powder, amorphous solid or oily liquid

Molecular weight: 214.05

Ref: 7W-GP1721

Carmustine

CAS: 154-93-8

Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.

Formula: C₅H₉Cl₂N₃O₂

Purity: 98% - 99.91%

Color and Shape: Light Yellow Powder Physical Description Orange-Yellow Solid (Ntp 1992)

Molecular weight: 214.05

Ref: TM-T3091

Carmustine

Controlled Product

CAS: 154-93-8

Stability Temperature Sensitive
Applications An alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),

Formula: C₅H₉Cl₂N₃O₂

Color and Shape: Light Yellow To Light Orange Colour

Molecular weight: 214.05

Ref: TR-C183875

Carmustine - Bio-X ™

CAS: 154-93-8

Carmustine is a DNA alkylating agent which also cross-links DNA. As a result, Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, means it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.

Formula: C₅H₉Cl₂N₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 214.05 g/mol

Ref: 3D-BC164289

Carmustine

CAS: 154-93-8

Carmustine is a DNA alkylating agent which also cross-links DNA. As a result Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, mean it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.

Formula: C₅H₉Cl₂N₃O₂

Purity: Min. 85%

Color and Shape: Powder

Molecular weight: 214.05 g/mol

Ref: 3D-FC19817

1,3-Bis(2-chloroethyl-d4)-1-nitrosourea

Controlled Product

CAS: 154-93-8

Applications 1,3-Bis(2-chloroethyl-d4)-1-nitrosourea is a useful isotopically labeled compound of Carmustine (C183875)

Formula: C₅D₈HCl₂N₃O₂

Color and Shape: Neat

Molecular weight: 222.09

Ref: TR-C183877