CAS 154040-19-4

amyloid protein non-A-beta component

Description:

Amyloid protein non-A-beta component, also known as the non-Aβ component of amyloid plaques, is a protein associated with neurodegenerative diseases, particularly Alzheimer's disease. This protein is part of the amyloid precursor protein (APP) pathway and is involved in the formation of amyloid plaques in the brain, which are characteristic of Alzheimer's pathology. The non-Aβ component is believed to play a role in the aggregation of amyloid-beta peptides, contributing to the overall amyloidogenic process. It is characterized by its ability to form fibrillar structures, which are insoluble aggregates that can disrupt cellular function and lead to neurotoxicity. The protein's structure typically includes regions that promote self-aggregation, and it may interact with other proteins and lipids in the cellular environment. Research into this protein is ongoing, as understanding its characteristics and interactions may provide insights into therapeutic strategies for Alzheimer's disease and other amyloid-related disorders.

Formula: C₁₄₁H₂₃₅N₃₉O₄₉

Synonyms:

• Non-A.beta. Component of Alzheimers Disease Amyloid
• H-Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val-OH

α-Synuclein (61-95) (human)

CAS: 154040-19-4

The 35 amino acid peptide NAC (α-synuclein (61-95)) has originally been isolated from the insoluble core of Alzheimer’s disease (AD) amyloid plaque. The sequence corresponds to a fragment of a 140 amino acid precursor known as NACP or α-synuclein and was found to form amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.

Formula: C₁₄₁H₂₃₅N₃₉O₄₉

Purity: 84.7%

Color and Shape: White

Molecular weight: 3260.65

Ref: 01-4026207

NAC

CAS: 154040-19-4

N-acetylcysteine (NAC) is a chemical that is used as an antioxidant and to help break down mucus. It also has been found to be helpful in treating many other conditions, including chronic bronchitis, emphysema, and chronic obstructive pulmonary disease. NAC appears to work by changing the way that cells respond to oxidative stress. When cells are exposed to high levels of reactive oxygen species (ROS), the cells produce more ROS in order to protect themselves from damage. NAC reduces the production of ROS when cells are exposed to oxidative stress, which protects against cellular damage. In addition, NAC may inhibit tumor growth by reducing the activity of certain proteins involved in cell division.

Formula: C₁₄₁H₂₃₅N₃₉O₄₉

Purity: Min. 95%

Molecular weight: 3,260.61 g/mol

Ref: 3D-FN108723