CAS 154765-05-6

ADRENOMEDULLIN (13-52) (HUMAN)

Description:

Adrenomedullin (13-52) is a peptide derived from the human adrenomedullin, a potent vasodilator involved in various physiological processes, including regulation of blood pressure and fluid balance. The specific sequence of this peptide, which is a fragment of the full-length adrenomedullin, contributes to its biological activity. It is characterized by its ability to bind to specific receptors, influencing cardiovascular functions and exhibiting neuroprotective properties. Adrenomedullin (13-52) is known for its role in promoting angiogenesis and modulating inflammatory responses. The CAS number 154765-05-6 uniquely identifies this compound in chemical databases, facilitating its study and application in research. This peptide is of interest in pharmacological studies, particularly in the context of cardiovascular diseases and potential therapeutic interventions. Its stability, solubility, and interaction with biological systems are key characteristics that researchers consider when exploring its applications in medicine and biotechnology.

Formula: C₂₀₀H₃₀₈N₅₈O₅₉S₂

InChI: InChI=1S/C31H39FN6O2/c1-40-28-4-2-3-25(32)24(28)18-38-17-22(9-11-27(38)19-5-6-19)34-31(39)20-7-10-26-23(15-20)30(36-35-26)21-8-12-29-33-13-14-37(29)16-21/h2-4,8,12-14,16,19-20,22-23,26-27,30,35-36H,5-7,9-11,15,17-18H2,1H3,(H,34,39)

InChI key: XJOVNCGUQXEANC-UHFFFAOYSA-N

SMILES: COC1=C(C(=CC=C1)F)CN2CC(CCC2C3CC3)NC(=O)C4CCC5C(C4)C(NN5)C6=CN7C=CN=C7C=C6

Synonyms:

• Sfgcrfgtctvqklahqiyqftdkdkdnvaprskispqgy-Nh2 (Disulfide Bridge: 4-9)
• Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-Nh2
• H-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-Nh2
• H-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-Nh2 (Disulfide Bridge: 4-9)

Adrenomedullin (13-52) (human)

CAS: 154765-05-6

This adrenomedullin fragment possessed vasodilatory activity. It has been suggested to modulate receptor-mediated, but not voltage-dependent, pulmonary vascular contraction by influencing Ca²⁺ influx. Therefore, it has been proposed that hADM (13-52) acts as an endothelium-dependent vasodilator agent in the pulmonary vascular bed of the rat. Furthermore, this compound may act as a modulator of the vascular phases of inflammation.

Formula: C₂₀₀H₃₀₈N₅₈O₅₉S₂

Purity: 94.8%

Color and Shape: White Whitish Powder

Molecular weight: 4533.13

Ref: 01-4034489

ADRENOMEDULLIN (13-52) (HUMAN)

CAS: 154765-05-6

ADRENOMEDULLIN (13-52) (HUMAN)

Formula: C₃₁H₃₉FN₆O₂

Purity: ≥95%

Molecular weight: 546.68

Ref: 54-PC1030382

Adrenomedullin (AM) (13-52), human

CAS: 154765-05-6

Adrenomedullin (AM) (13-52), human is a CGRP-family vasodilator peptide regulating vascular tone.

Formula: C₂₀₀H₃₀₈N₅₈O₅₉S₂

Purity: 98.51%

Color and Shape: White Solid

Molecular weight: 4533.10

Ref: TM-TP1857

ADRENOMEDULLIN (13-52) (HUMAN)

CAS: 154765-05-6

Formula: C₃₁H₃₉FN₆O₂

Color and Shape: Solid

Molecular weight: 546.6788

Ref: IN-DA00AP92