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CAS 155178-13-5

:

amyloid beta-protein (17-42)

Description:
Amyloid beta-protein (17-42), often referred to as Aβ(17-42), is a peptide fragment derived from the amyloid precursor protein (APP) and is associated with Alzheimer's disease. This specific fragment consists of 26 amino acids, starting from the 17th to the 42nd position of the full-length amyloid beta peptide. Aβ(17-42) is known for its propensity to aggregate, forming oligomers and fibrils that are implicated in neurotoxicity and the pathogenesis of Alzheimer's disease. The peptide is hydrophobic, which contributes to its aggregation properties, and it can interact with cell membranes, potentially disrupting cellular function. Aβ(17-42) is also studied for its role in neuroinflammation and synaptic dysfunction. Its CAS number, 155178-13-5, allows for precise identification in chemical databases. Research continues to explore its structure, aggregation mechanisms, and potential as a therapeutic target in neurodegenerative diseases. Understanding the characteristics of Aβ(17-42) is crucial for developing strategies to mitigate its harmful effects in the brain.
Formula:C119H194N28O33S
InChI:InChI=1/C119H194N28O33S/c1-25-65(18)96(113(173)127-55-86(152)131-77(47-59(6)7)106(166)135-76(43-45-181-24)104(164)142-91(60(8)9)111(171)125-52-84(150)123-53-88(154)140-93(62(12)13)115(175)144-95(64(16)17)116(176)147-97(66(19)26-2)117(177)130-70(23)119(179)180)146-118(178)98(67(20)27-3)145-100(160)68(21)128-85(151)54-124-102(162)74(40-34-35-44-120)134-108(168)80(50-83(122)149)137-110(170)82(57-148)132-87(153)56-126-112(172)92(61(10)11)143-109(169)81(51-90(157)158)138-103(163)75(41-42-89(155)156)133-99(159)69(22)129-105(165)78(48-71-36-30-28-31-37-71)136-107(167)79(49-72-38-32-29-33-39-72)139-114(174)94(63(14)15)141-101(161)73(121)46-58(4)5/h28-33,36-39,58-70,73-82,91-98,148H,25-27,34-35,40-57,120-121H2,1-24H3,(H2,122,149)(H,123,150)(H,124,162)(H,125,171)(H,126,172)(H,127,173)(H,128,151)(H,129,165)(H,130,177)(H,131,152)(H,132,153)(H,133,159)(H,134,168)(H,135,166)(H,136,167)(H,137,170)(H,138,163)(H,139,174)(H,140,154)(H,141,161)(H,142,164)(H,143,169)(H,144,175)(H,145,160)(H,146,178)(H,147,176)(H,155,156)(H,157,158)(H,179,180)/t65-,66-,67-,68-,69-,70-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,91-,92-,93-,94-,95-,96-,97-,98-/m0/s1
InChI key:IJFDWFCPZVWUDC-FWKDGKLYSA-N
SMILES:CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N
Synonyms:
  • L-Leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine
  • Amyloid beta-protein (17-42)
  • Abeta 17-42
  • beta-Amyloid peptide 17-42
  • L-Alanine, L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-
  • L-Alanine, L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-
Found 2 products.
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    Bachem
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    Amyloid β-Protein (17-42)

    CAS:
    Formula:C119H194N28O33S
    Molecular weight:2577.08

    Ref: 01-0

    0.5mg
    285.00€
    1mg
    953.00€
  • CymitQuimica logo
    Bachem
    + Info

    Amyloid β-Protein (17-42)

    CAS:
    Cleavage of APP by alpha- and gamma secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. Aβ 17–42 contains the two hydrophobic patches (L17-A21 and A30–A42) and the turn region (E22-G29) that are crucial for determining aggregation and toxicity and form the strand-loop-strand conformation in fibrils.
    Formula:C119H194N28O33S
    Purity:90.5%
    Color and Shape:White
    Molecular weight:2577.08

    Ref: 01-4050878

    0.5mg
    351.00€
    1mg
    1,177.00€