CAS 155558-32-0

HYDROXYFASUDIL MONOHYDROCHLORIDE

Description:

Hydroxyfasudil monohydrochloride is a chemical compound that serves as a selective Rho kinase inhibitor, primarily studied for its potential therapeutic applications in various medical conditions, including neurological disorders and cardiovascular diseases. It is characterized by its ability to modulate cellular signaling pathways, particularly those involved in smooth muscle contraction and cell migration. The compound is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits stability under standard laboratory conditions. Its molecular structure includes a hydroxyl group, contributing to its pharmacological properties. Hydroxyfasudil monohydrochloride has been investigated for its effects on improving blood flow and reducing tissue damage in ischemic conditions. As with many pharmacological agents, its use may be associated with specific side effects and contraindications, necessitating careful consideration in clinical applications. Overall, this compound represents a significant area of research in the development of targeted therapies for complex diseases.

Formula: C₁₄H₁₈ClN₃O₃S

Synonyms:

• 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
• Hydroxyfasudil Hydrochloride
• 1-(1-Hydroxy-5-Isoquinolinesulfonyl)Homopiperazine Monohydrochloride
• Hydroxyfasudil HCl
• Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
• Hydroxyfasudil hydrochloride hydrate
• 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride
• Hydroxyfasudil hydrochloride (HA-1100 hydrochloride)
• HYDROXYFASUDIL MONOHYDROCHLORIDE
• 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
• Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
• HA-1100 HYDROCHLORIDE;HA 1100 HYDROCHLORIDE;HA1100 HYDROCHLORIDE
• Hydroxyfasudil (HA-1100)
• Hydroxyfasudil (HA-1100) HCl
• 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
• 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
• Fasudil Impurity 7 HCl
• 5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one

1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)

CAS: 155558-32-0

Formula: C₁₄H₁₈ClN₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 343.8290

Ref: IN-DA001O01

Hydroxyfasudil Hydrochloride

CAS: 155558-32-0

Hydroxyfasudil Hydrochloride

Purity: ≥98%

Molecular weight: 343.83g/mol

Ref: 54-BUP05902

Hydroxyfasudil hydrochloride

CAS: 155558-32-0

Formula: C₁₄H₁₇N₃O₃S·HCl

Molecular weight: 343.8

Ref: 7W-GA2974

Hydroxyfasudil Hydrochloride

CAS: 155558-32-0

Formula: C₁₄H₁₇N₃O₃S·HCl

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 343.83

Ref: 3B-H1745

Hydroxyfasudil Hydrochloride

CAS: 155558-32-0

Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).

Formula: C₁₄H₁₈ClN₃O₃S

Purity: 98.05%

Color and Shape: Solid

Molecular weight: 343.83

Ref: TM-T4276

Hydroxy Fasudil Hydrochloride

Controlled Product

CAS: 155558-32-0

Applications A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.
References Shimokawa, H., et al.: Cardiovasc. Res., 43, 1029 (1999), Takemoto, M., et al.: Circulation, 106, 57 (2002), Ito, K., et al.: J. Physiol., 546, 823 (2003),

Formula: C₁₄H₁₇N₃O₃S·ClH

Color and Shape: Neat

Molecular weight: 343.83

Ref: TR-H942380