CAS 155558-32-0
:HYDROXYFASUDIL MONOHYDROCHLORIDE
Description:
Hydroxyfasudil monohydrochloride is a chemical compound that serves as a selective Rho kinase inhibitor, primarily studied for its potential therapeutic applications in various medical conditions, including neurological disorders and cardiovascular diseases. It is characterized by its ability to modulate cellular signaling pathways, particularly those involved in smooth muscle contraction and cell migration. The compound is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits stability under standard laboratory conditions. Its molecular structure includes a hydroxyl group, contributing to its pharmacological properties. Hydroxyfasudil monohydrochloride has been investigated for its effects on improving blood flow and reducing tissue damage in ischemic conditions. As with many pharmacological agents, its use may be associated with specific side effects and contraindications, necessitating careful consideration in clinical applications. Overall, this compound represents a significant area of research in the development of targeted therapies for complex diseases.
Formula:C14H18ClN3O3S
InChI:InChI=1S/C14H17N3O3S.ClH/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17;/h1,3-5,7,15H,2,6,8-10H2,(H,16,18);1H
InChI key:XWWFOUVDVJGNNG-UHFFFAOYSA-N
SMILES:C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
Synonyms:- 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
- Hydroxyfasudil Hydrochloride
- 1-(1-Hydroxy-5-Isoquinolinesulfonyl)Homopiperazine Monohydrochloride
- Hydroxyfasudil HCl
- Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
- Hydroxyfasudil hydrochloride hydrate
- 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride
- Hydroxyfasudil hydrochloride (HA-1100 hydrochloride)
- HYDROXYFASUDIL MONOHYDROCHLORIDE
- 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
- Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
- HA-1100 HYDROCHLORIDE;HA 1100 HYDROCHLORIDE;HA1100 HYDROCHLORIDE
- Hydroxyfasudil (HA-1100)
- Hydroxyfasudil (HA-1100) HCl
- 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
- 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
- Fasudil Impurity 7 HCl
- 5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one
- See more synonyms
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Hydroxyfasudil Hydrochloride
CAS:Formula:C14H17N3O3S·HClPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:343.83Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil HydrochlorideFormula:C14H18ClN3O3SPurity:98%Molecular weight:343.831(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
CAS:Formula:C14H18ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:343.8290Hydroxy Fasudil Hydrochloride
CAS:Controlled ProductApplications A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.
References Shimokawa, H., et al.: Cardiovasc. Res., 43, 1029 (1999), Takemoto, M., et al.: Circulation, 106, 57 (2002), Ito, K., et al.: J. Physiol., 546, 823 (2003),Formula:C14H17N3O3S·ClHColor and Shape:NeatMolecular weight:343.83Hydroxyfasudil Hydrochloride
CAS:Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).Formula:C14H18ClN3O3SPurity:98.03%Color and Shape:White SolidMolecular weight:343.83
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