CAS 155877-83-1

4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID

Description:

4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid, with CAS number 155877-83-1, is a complex organic compound characterized by its multi-ring structure, which includes both a benzoic acid moiety and a diazepine framework. This compound features a tetrahydro structure that contributes to its unique stereochemistry and potential biological activity. The presence of multiple methyl groups enhances its hydrophobic character, which may influence its solubility and interaction with biological membranes. The compound's intricate structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting neurological or psychological conditions, given the diazepine component's known pharmacological properties. Additionally, the presence of the benzoic acid group may impart acidity and reactivity, making it a candidate for further chemical modifications. Overall, this substance exemplifies the complexity and diversity of organic compounds in medicinal chemistry.

Formula: C₂₉H₃₀N₂O₂

InChI: InChI=1/C29H30N2O2/c1-28(2)14-15-29(3,4)22-17-25-23(16-21(22)28)30-26(18-10-12-19(13-11-18)27(32)33)20-8-6-7-9-24(20)31(25)5/h6-13,16-17H,14-15H2,1-5H3,(H,32,33)

SMILES: CC1(C)CCC(C)(C)c2cc3c(cc12)N=C(c1ccc(cc1)C(=O)O)c1ccccc1N3C

Synonyms:

• Le 135
• 4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-(5H)-benzo[e]naphtho[2.3-b][1.4]diazepine-13-yl)benzoicacid
• 4-(5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid
• Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentaMethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-
• 4-(7,8,9,10-TETRAHYDRO-5,7,7,10,10-PENTAMETHYL-5H-BENZO[E]NAPHTHO[2,3-B][1,4]DIAZEPIN-13-YL)BENZOIC ACID

Benzoic acid, 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-

CAS: 155877-83-1

Formula: C₂₉H₃₀N₂O₂

Purity: 98%

Molecular weight: 438.5607

Ref: IN-DA001OAQ

LE135

CAS: 155877-83-1

LE135

Purity: ≥95%

Molecular weight: 438.56g/mol

Ref: 54-BUP03946

LE 135

Controlled Product

CAS: 155877-83-1

Formula: C₂₉H₃₀N₂O₂

Color and Shape: Neat

Molecular weight: 438.561

Ref: TR-L320000

LE 135

Controlled Product

CAS: 155877-83-1

LE 135 is a synthetic retinoid that has been shown to have cell signaling and cytotoxic effects on k562 cells. It binds to the response element of the gene encoding dopamine β-hydroxylase, a key enzyme in the synthesis of dopamine, and inhibits its activity. LE 135 also induces axonal growth by activating the Wnt/β-catenin signaling pathway, which causes neural stem cells to differentiate into neurons. In addition, LE 135 stimulates pluripotent cells to differentiate into hepatocytes, which are liver cells responsible for detoxifying various substances.

Formula: C₂₉H₃₀N₂O₂

Purity: Min. 95%

Molecular weight: 438.56 g/mol

Ref: 3D-FGA87783

LE135

CAS: 155877-83-1

LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).

Formula: C₂₉H₃₀N₂O₂

Purity: 97.94%

Color and Shape: Solid

Molecular weight: 438.56

Ref: TM-T22920