CAS 15663-27-1

Cisplatin

Description:

Cisplatin, with the CAS number 15663-27-1, is a platinum-based chemotherapy drug widely used in the treatment of various cancers, including testicular, ovarian, bladder, and lung cancers. Its chemical formula is cis-[Pt(NH3)2Cl2], indicating that it consists of a platinum atom coordinated to two ammonia molecules and two chloride ions. The compound is characterized by its square planar geometry, which is crucial for its biological activity. Cisplatin functions primarily by forming DNA cross-links, thereby inhibiting DNA replication and transcription, leading to apoptosis in rapidly dividing cancer cells. It is typically administered intravenously and can have side effects such as nephrotoxicity, nausea, and myelosuppression. The drug's effectiveness can be influenced by factors such as the presence of specific cellular proteins and the tumor microenvironment. Due to its mechanism of action, cisplatin is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy and overcome resistance.

Formula: Cl₂H₆N₂Pt

InChI: InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key: InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L

SMILES: [Pt+2]([Cl-])([Cl-])([NH3])[NH3]

Synonyms:

• (SP-4-2)-Diamminedichloroplatinum
• Abiplatin
• Biocisplatinum
• Briplatin
• CP Ethypharm
• Cacp
• Cddp
• Cis-Platinum(Ii)Diammine Dichloride
• Cismaplat
• Cisplatin
• Cisplatine
• Cisplatine Mylan
• Cisplatino
• Cisplatinum
• Cisplatyl
• Citoplatino
• Citoplax
• Cpdc
• Cpdd
• Cppd
• DDP
• DDP (antitumor agent)
• DichlorodiammineplatinumIIyelloworangextl
• Fauldiscipla
• IA-call
• Kemoplat
• Lederplatin
• LiPlaCis
• Lipoplatin
• Maruko
• Neoplatin
• Nsc 119875
• Platamine
• Platiblastin
• Platidiam
• Platinex
• Platinol
• Platinol AQ
• Platinoxan
• Platinum, diamminedichloro-, (SP-4-2)-
• Platinum, diamminedichloro-, cis-
• Platinumdiamminechloride
• Platistin
• Platosin
• Rand
• Randa
• SPI 077 (complex)
• Spi 077
• Spi 077B103
• Tr 170
• cis-DDP
• cis-Diaminedichloridoplatinum(II)
• cis-Diaminedichloroplatinum
• cis-Diaminedichloroplatinum(II)
• cis-Diaminodichloroplatinum(II)
• cis-Diamminedichloroplatinum
• cis-Diamminedichloroplatinum(II)
• cis-Diammineplatinum(II)
• cis-Diammineplatinum(II) dichloride
• cis-Dichlorodiammineplatinum
• cis-Dichlorodiammineplatinum(II)
• cis-Platin
• cis-Platine
• cis-Platinous diaminodichloride
• cis-Platinum
• cis-Platinum II
• cis-Platinum diaminodichloride
• cis-Platinum(II) diaminodichloride
• cis-Platinum(II) diammine chloride
• cis-Platinum(II) diamminedichloride
• cis-Platinumdiamine dichloride
• cis-Platinumdiammine dichloride

cis-Diammineplatinum(II) Dichloride

CAS: 15663-27-1

Formula: H₆Cl₂N₂Pt

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 300.05

Ref: 3B-D3371

cis-Diamminedichloroplatinum(II), Pt 64.5% min

CAS: 15663-27-1

Being a potent anticancer agent that blocks DNA synthesis, the pharmaceutical compositions are used in chemotherapy. First member of platinum-containing anti-cancer drugs. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and

Formula: Cl₂H₆N₂Pt

Purity: 64.5%

Molecular weight: 300.04

Ref: 02-010471

cis-Dichlorodiammine platinum(II), 99% CISPLATIN

CAS: 15663-27-1

cis-Dichlorodiammine platinum(II), 99% CISPLATIN

Formula: cisPt(NH₃)₂Cl₂

Purity: 99%

Color and Shape: yellow to orange xtl.

Molecular weight: 300.06

Ref: 08-78-0450

CISPLATIN RS

CAS: 15663-27-1

CISPLATIN RS

Formula: H₄Cl₂N₂Pt

Color and Shape: Powder

Molecular weight: 298.0352

Ref: 41-ICRS0258

Cisplatin

CAS: 15663-27-1

Cisplatin

Formula: Cl₂H₆N₂Pt

Purity: 100.0%

Color and Shape: Yellow

Molecular weight: 298.9556

Ref: 47-809

CISPLATIN CRS

CAS: 15663-27-1

CISPLATIN CRS

Formula: H₄Cl₂N₂Pt

Color and Shape: Powder

Molecular weight: 298.0352

Ref: 41-C2210000

Cisplatin

CAS: 15663-27-1

Inorganic or organic compounds of precious metals, whether or not chemically defined; amalgrams of precious metals, nesoi

Formula: Cl₂H₆N₂Pt

Color and Shape: Yellow Orange Powder

Molecular weight: 298.9556

Ref: 45-1134357

dichloroplatinum diamine

CAS: 15663-27-1

Formula: Cl₂H₆N₂Pt

Purity: 99%

Color and Shape: Solid

Molecular weight: 300.0450

Ref: IN-DA0034MA

Cisplatin

CAS: 15663-27-1

Cisplatin (CDDP) is a DNA cross-linking agent.

Formula: Cl₂H₆N₂Pt

Purity: 97.13% - 99.63%

Color and Shape: Orange-Yellow To Deep Yellow Solid Or Powder

Molecular weight: 300.04

Ref: TM-T1564

Cisplatin

CAS: 15663-27-1

Cisplatin

Purity: ≥95%

Molecular weight: 300.04g/mol

Ref: 54-BUP15896

Cisplatin, USP grade

CAS: 15663-27-1

Formula: Cl₂H₆N₂Pt

Purity: ≥ 4.5

Color and Shape: Yellow to orange powder

Molecular weight: 300.06

Ref: 7W-GP5927

Cisplatin

CAS: 15663-27-1

Formula: Cl₂H₆N₂Pt

Purity: ≥ 98.0% (anhydrous)

Color and Shape: Yellow to orange powder

Molecular weight: 300.06

Ref: 7W-GA8978

Cisplatin

CAS: 15663-27-1

Formula: Cl₂H₆N₂Pt

Color and Shape: Yellow Solid

Molecular weight: 300.05

Ref: 4Z-C-236001

cis-Dichlorodiamine platinum(II); 99.95% (metals basis)

CAS: 15663-27-1

Formula: Pt(NH₃)₂Cl₂

Purity: ≥ 99.95%

Color and Shape: Yellow to orange powder or crystals

Molecular weight: 300.06

Ref: 7W-GX4154

Cisplatin RS

CAS: 15663-27-1

Color and Shape: Yellow Solid Crystalline Powder

Ref: 2K-1066000021

Cisplatin

Controlled Product

CAS: 15663-27-1

Formula: Cl₂H₆N₂Pt

Color and Shape: Neat

Molecular weight: 300.04

Ref: TR-C499500

Cisplatin - Bio-X ™

CAS: 15663-27-1

Cisplatin, also known as cisplatinum, is a platinum-based anti-cancer agent that inhibits the EGFR, which is a receptor tyrosine kinase. It has been shown to have anti-cancer effects in melanoma cells and to inhibit tumor growth in mice. Cisplatin acts by interfering with the mechanism of DNA repairing. It loses one chloride ligand and binds to DNA to inhibit the synthesis, causing DNA damage, and thus inducing apoptosis in cancer cells. In certain studies, the use of cisplatin in combination with other metal chelators has shown improvement in the uptake of the anticancer drug. CisplatiN - Bio-X™ is part of our Bio-X™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: Cl₂H₆N₂Pt

Purity: Min. 99%

Color and Shape: Powder

Molecular weight: 300.05 g/mol

Ref: 3D-BC164315

Cisplatin

CAS: 15663-27-1

Cisplatin is a chemotherapeutic drug that inhibits the growth of cancer cells by binding to DNA. It binds to DNA and inhibits transcription and replication, leading to the accumulation of p-glycoprotein (P-gp) inhibitor in the cell membrane, which prevents the efflux of intracellular caspase activators. This leads to an increase in apoptosis among cancer cells and a decrease in healthy tissue. The toxicology of cisplatin has been studied extensively, with low-dose groups showing no signs of toxicity.

Formula: Cl₂H₆N₂Pt

Purity: (Hplc) 98 To 102%

Color and Shape: Yellow Powder

Molecular weight: 300.05 g/mol

Ref: 3D-FC20460

Cisplatin

CAS: 15663-27-1

Purity: 98%

Molecular weight: 298.96

Ref: 10-F554436

cis-Dichlorodiammineplatinum (II), CISPLATIN (USP)

CAS: 15663-27-1

cis-Dichlorodiammineplatinum (II), CISPLATIN (USP)

Formula: cisPt(NH₃)₂Cl₂

Color and Shape: yellow to orange xtl.

Molecular weight: 300.06

Ref: 08-78-0455