CAS 158442-41-2

N-cbz-ile-glu(O-T-butyl)-ala-leucinal

Description:

N-Cbz-ile-glu(O-T-butyl)-ala-leucinal, with the CAS number 158442-41-2, is a synthetic compound that belongs to the class of peptides and peptide derivatives. It features a Cbz (benzyloxycarbonyl) protecting group, which is commonly used in peptide synthesis to protect the amino group of the amino acid. The compound contains isoleucine (ile), glutamic acid (glu) with a tert-butyl ester modification, alanine (ala), and leucine (leucinal), indicating a complex structure that may exhibit specific biological activities. The presence of the tert-butyl group enhances the lipophilicity of the glutamic acid residue, potentially influencing the compound's solubility and permeability. This compound may be of interest in medicinal chemistry and drug development, particularly in the design of peptide-based therapeutics. Its characteristics, including stability, reactivity, and biological activity, would depend on the specific context of its use and the conditions under which it is studied. Further research would be necessary to elucidate its full potential and applications in various fields.

Formula: C₃₂H₅₀N₄O₈

Synonyms:

• Proteasome Inhibitor I
• N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide
• PROTEASOME INHIBITOR I USP/EP/BP
• N-CBZ-ILE-GLU(O-T-BUTYL)-ALA-LEUCINAL
• Z-IE(OTBU)AL-CHO
• arbobenzoxy-l-isoleucyl-gamma-t-butyl-l-glutamyl-l-alanyl-l-leucinal
• M.W. 618.77 C32H50N4O8
• Z-ILE-GLU(OBUT)-ALA-LEU-H
• PSI PROTEASOME INHIBITOR I
• CBZ-Ile-Glu(OtBu)-Ala-Leu-aldehyde
• ProteasoMe Inhibitor 1
• Z-ILE-GLU(OTBU)-ALA-LEU-ALDEHYDE
• Z-ILE-GLU(OTBU)-ALA-LEU-CHO
• PROTEASOME INHIBITOR I (ALDEHYDE)
• CS-1340
• Cbz-Ile-Glu(OtBu)-Ala-Leu-al
• z-ile-glu(o-t-butyl)-ala-leucinal
• PROTEASOME INHIBITOR PSI
• Z-ILE-GLU(OBUT)-ALA-LEU-H (ALDEHYDE)
• PROTEASOME INHIBITOR I ;Z-ILE-GLU(OTBU)-ALA-LEU-CHO
• BENZYLOXYCARBONYL-L-ISOLEUCYL-[(2S)-2-AMINO-4-(T-BUTYLOXYCARBONYL)BUTANOYL]-L-ALANYL-L-LEUCINAL
• L-AlaninaMide, N-[(phenylMethoxy)carbonyl]-L-isoleucyl-L-a-glutaMyl-N-[(1S)-1-forMyl-3 -Methylbutyl]-, 1,1-diMethylethyl ester
• PSI
• CARBOBENZOXY-L-ISOLEUCYL-GAMMA-T-BUTYL-L-GLUTAMYL-L-ALANYL-L-LEUCINAL
• L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester
• N-Cb
• N-carbobenzyloxy-Ile-Glu(O-tert-butyl)-Ala-leucinal

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

CAS: 158442-41-2

Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.

Formula: C₃₂H₅₀N₄O₈

Purity: ≥ 95%

Color and Shape: White

Molecular weight: 618.77

Ref: 01-4026408

L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester

CAS: 158442-41-2

Formula: C₃₂H₅₀N₄O₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 618.7614

Ref: IN-DA001Q6O

Z-Ile-Glu(O-t-butyl)-Ala-Leucinal

CAS: 158442-41-2

Formula: C₃₂H₅₀N₄O₈

Purity: ≥ 90.0%

Color and Shape: White solid

Molecular weight: 618.76

Ref: 7W-GK8272

Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dap(Dnp)-NH2

CAS: 158442-41-2

Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dap(Dnp)-NH2 is a synthetic peptide that binds to the toll receptor. The binding of this peptide leads to the signal pathways, which are responsible for the body formation. Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser Arg Dap (Dnp) -NH2 has been shown to have an antiinflammatory effect in rats. This peptide also has a dna binding activity and can be used as a marker for granule neurons in the brain.

Formula: C₅₉H₉₃N₂₃O₂₀

Purity: Min. 95%

Molecular weight: 1,444.54 g/mol

Ref: 3D-SDP-3818-PI

Z-Ile-Glu(OtBu)-Ala-Leu-H (aldehyde)

CAS: 158442-41-2

inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex in HT4 cells.  Causes accumulation of ubiquitinylated proteins in neuronal cells.

Formula: C₃₂H₅₀N₄O₈

Purity: Min. 95%

Molecular weight: 618.76 g/mol

Ref: 3D-IAT-3169-V

Z-Ile-Glu(OtBu)-Ala-Leu-H (aldehyde)

CAS: 158442-41-2

Please enquire for more information about Z-Ile-Glu(OtBu)-Ala-Leu-H (aldehyde) including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₃₂H₅₀N₄O₈

Molecular weight: 618.76 g/mol

Ref: 3D-IAT-3169

PSI

CAS: 158442-41-2

PSI is a proteasome inhibitor.

Formula: C₃₂H₅₀N₄O₈

Purity: 97% - 98.33%

Color and Shape: Solid

Molecular weight: 618.76

Ref: TM-T21510

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

CAS: 158442-41-2

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde, also known as ZILEAL, is a potent immunosuppressant that binds to the Toll-like receptor (TLR) and inhibits NF-κB binding activity. It has been shown to reduce the activation of macrophages by inhibiting the production of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα), IL-1β, and IL-6. This drug has been shown to inhibit HIV replication in vitro and was also found to have an antiviral effect against herpes simplex virus type 1 in vivo. ZILEAL also inhibits dsDNA binding activity, which may have potential applications in cancer treatment.

Formula: C₃₂H₅₀N₄O₈

Purity: Min. 95%

Molecular weight: 618.76 g/mol

Ref: 3D-FI111570