CAS 159013-54-4

BIBP 3226

Description:

BIBP 3226, with the CAS number 159013-54-4, is a selective antagonist of the neuropeptide Y (NPY) Y1 receptor. This compound is primarily utilized in research settings to investigate the physiological roles of NPY and its receptors, particularly in the context of appetite regulation, anxiety, and cardiovascular functions. BIBP 3226 exhibits high affinity for the Y1 receptor, making it a valuable tool for studying the receptor's signaling pathways and potential therapeutic applications. The compound is typically characterized by its ability to inhibit NPY-induced responses, thus providing insights into the mechanisms of NPY-related processes. In terms of its chemical structure, BIBP 3226 features specific functional groups that contribute to its receptor-binding properties. As with many research chemicals, safety and handling precautions are essential, as the compound may have specific toxicity profiles or require careful storage conditions. Overall, BIBP 3226 serves as an important compound in neuropharmacological research, aiding in the understanding of neuropeptide signaling.

Formula: C₂₇H₃₁N₅O₃

InChI: InChI=1S/C27H31N5O3/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30)/t23-/m1/s1

InChI key: InChIKey=KUWBXRGRMQZCSS-HSZRJFAPSA-N

SMILES: C(C(N[C@@H](C(NCC1=CC=C(O)C=C1)=O)CCCNC(=N)N)=O)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• (2R)-5-(Diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide
• Benzeneacetamide,N-[4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-a-phenyl-, (R)-
• Bibp 3226
• N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide
• Benzeneacetamide, N-[(1R)-4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenyl-

BIBP3226

CAS: 159013-54-4

The Y₁ receptor antagonist BIBP-3226, a derivative of D-arginine, binds to the Y₁ receptor with high affinity (its Ki was 7 nM versus the Ki of 0.2 nM for NPY). BIBP3226 also reduced the NPY-induced increase in intracellular calcium as well as the pressor response in vitro and in vivo. BIBP3226 inhibited NPY induced feeding in rats. In dogs, intra-arterial infusion of BIBP-3226 interrupted tonic NPY Y1 receptor-mediated vasoconstriction in exercising skeletal muscle, resulting in substantial increases in experimental limb blood flow. CAS-Number (trifluoroacetate): 1068148-47-9.

Formula: C₂₇H₃₁N₅O₃

Purity: 98.8%

Color and Shape: White Powder

Molecular weight: 473.58

Ref: 01-4034548

BIBP 3226

CAS: 159013-54-4

Formula: C₂₇H₃₁N₅O₃

Molecular weight: 473.57

Ref: 7W-GK3494

BIBP 3226 trifluoroacetate

CAS: 159013-54-4

Formula: C₂₇H₃₁N₅O₃·CF₃CO₂H

Purity: ≥ 98.0% (HPLC)

Color and Shape: White solid or powder

Molecular weight: 587.59

Ref: 7W-GX7809

BIBP3226

CAS: 159013-54-4

BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor.

Formula: C₂₇H₃₁N₅O₃

Color and Shape: Solid

Molecular weight: 473.57

Ref: TM-T26801

BIBP 3226

CAS: 159013-54-4

BIBP 3226 is a drug that belongs to the class of beta-blockers. It is a potent and selective beta-adrenergic receptor antagonist that has been shown to have maximal response in the concentration range of 1 nM to 10 micromolar. The effects on blood pressure are dose dependent, with a maximal effect at doses greater than or equal to 0.1 mg/kg. BIBP 3226 has been found to inhibit insulin resistance and increase cardiac contractility in rats, and may also have an inhibitory effect on platelet aggregation. This drug exhibits pharmacokinetic properties that are independent of food intake and is metabolized by CYP3A4 in the liver.

Formula: C₂₉H₃₂F₃N₅O₅

Purity: Min. 95%

Molecular weight: 587.6 g/mol

Ref: 3D-JGA01354