CAS 15917-65-4

N-Desmethyl Tamoxifen Hydrochloride

Description:

N-Desmethyl Tamoxifen Hydrochloride, with the CAS number 15917-65-4, is a derivative of the selective estrogen receptor modulator (SERM) tamoxifen. It is characterized by its role as an active metabolite of tamoxifen, which is primarily used in the treatment of estrogen receptor-positive breast cancer. This compound exhibits anti-estrogenic properties, particularly in breast tissue, while displaying estrogenic effects in other tissues, such as bone and endometrium. N-Desmethyl Tamoxifen Hydrochloride is typically a white to off-white crystalline powder, soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO), but has limited solubility in water. Its pharmacokinetics involve metabolism primarily in the liver, where it undergoes further biotransformation. The compound's efficacy and safety profile make it a subject of interest in both clinical and research settings, particularly in understanding resistance mechanisms in breast cancer therapy. As with any pharmaceutical agent, its use should be guided by appropriate medical advice and regulatory standards.

Formula: C₂₅H₂₈ClNO

InChI: InChI=1/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

InChI key: GMLHJWZEYLTNJW-BJFQDICYSA-N

SMILES: CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCNC)/c1ccccc1.Cl

Synonyms:

• N-Demethyltamoxifen Hydrochlorid
• (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N-methylethanamine Hydrochloride
• 2-{4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N-methylethanamine
• 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N-methyl-ethanamine hydrochloride

N-Desmethyltamoxifen hydrochloride

CAS: 15917-65-4

N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.

Formula: C₂₅H₂₈ClNO

Purity: 99.15%

Color and Shape: Solid

Molecular weight: 393.949

Ref: TM-T12148

N-Desmethyltamoxifen hydrochloride

CAS: 15917-65-4

Formula: C₂₅H₂₇NO·HCl

Molecular weight: 393.95

Ref: 7W-GK5368

N-Desmethyltamoxifen hydrochloride

CAS: 15917-65-4

N-Desmethyltamoxifen hydrochloride

Formula: C₂₅H₂₈ClNO

Purity: 99%

Molecular weight: 393.95

Ref: 54-BUP16176

Tamoxifen EP Impurity F HCl

CAS: 15917-65-4

Formula: C₂₅H₂₇NO·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 357.50 36.46

Ref: 4Z-T-011

(Z)-2-(4-(1,2-Diphenylbut-1-en-1-yl)phenoxy)-N-methylethanamine hydrochloride

CAS: 15917-65-4

Formula: C₂₅H₂₈ClNO

Purity: 98%

Color and Shape: Solid

Molecular weight: 393.9489

Ref: IN-DA001QJI

Tamoxifen Citrate EP Impurity F (as Hydrochloride)

Controlled Product

CAS: 15917-65-4

Formula: C₂₅H₂₇NO·ClH

Color and Shape: Neat

Molecular weight: 393.95

Ref: 86-MM0053.12

N-Desmethyl Tamoxifen Hydrochloride

CAS: 15917-65-4

Applications A main metabolite of the anti-cancer drug Tamoxifen (T006000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fabian, C., et al.: Biopharm. Drug Dispos., 2, 381 (1981), Jordan, V., et al.: Breast Cancer Res. Treat., 15, 125 (1990), Mandlekar, S., et al.: Cancer Res., 60, 6601 (2000), Lim, Y., et al.: Cancer Chemother. Pharmacol., 55, 471 (2005), Rouanet, P., et al.: J. Clin. Oncol., 2005, 23, 2980 (2005)

Formula: C₂₅H₂₇NO·ClH

Color and Shape: Neat

Molecular weight: 393.95

Ref: TR-D293900

Tamoxifen EP Impurity C

CAS: 15917-65-4

Formula: C₂₄H₂₅NO

Color and Shape: White To Off-White Solid

Molecular weight: 343.47

Ref: 4Z-T-0115

N-Desmethyltamoxifen hydrochloride

CAS: 15917-65-4

Formula: C₂₅H₂₈ClNO

Molecular weight: 393.9

Ref: BE-RMCT016001

N-Desmethyl tamoxifen hydrochloride

CAS: 15917-65-4

N-Desmethyl tamoxifen hydrochloride is a non-steroidal antiestrogen that competes with estradiol for estrogen receptors. It is used in the treatment of breast cancer, as well as other cancers that require antiestrogens, such as prostate cancer or endometrial cancer. Tamoxifen has been shown to be effective in palliative treatment and palliative care, which are treatments that provide relief from pain and other symptoms without curing the disease. Tamoxifen also reduces the risk of recurrence of breast cancer by about 50%.

Formula: C₂₅H₂₈ClNO

Purity: Min. 95%

Molecular weight: 393.95 g/mol

Ref: 3D-FD21327