CAS 160707-69-7

Apricitabine

Description:

Apricitabine, also known by its developmental code name ATC code, is a nucleoside reverse transcriptase inhibitor (NRTI) primarily investigated for the treatment of HIV infection. It is characterized by its ability to inhibit the reverse transcriptase enzyme, which is crucial for the replication of the HIV virus. The chemical structure of Apricitabine features a modified nucleoside backbone, which enhances its efficacy and resistance profile compared to other NRTIs. Its mechanism of action involves incorporation into the viral DNA, leading to chain termination during viral replication. Apricitabine has shown activity against various HIV strains, including those resistant to other NRTIs. Additionally, it has a favorable pharmacokinetic profile, allowing for once-daily dosing. However, like other antiretroviral agents, it may be associated with side effects, including potential mitochondrial toxicity. Research and clinical trials have explored its safety and effectiveness, contributing to the understanding of HIV treatment regimens. As of the latest updates, Apricitabine has not received widespread approval for clinical use, but it remains a subject of interest in HIV research.

Formula: C₈H₁₁N₃O₃S

InChI: InChI=1/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m1/s1

InChI key: InChIKey=RYMCFYKJDVMSIR-RNFRBKRXSA-N

SMILES: O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1

Synonyms:

• (-)-2′-Deoxy-3′-oxa-4′-thiocytidine
• (-)-Bch 10652
• 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.
• 2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-
• 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-, (2R-cis)-
• 4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone
• Avx 754
• Bch 10618
• Spd 754
• APRICITABINE
• (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (Apricitabine)
• Avx754
• 4-Amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one
• Unii-K1yx059ml1

2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-

CAS: 160707-69-7

Formula: C₈H₁₁N₃O₃S

Purity: 95%

Molecular weight: 229.25624000000002

Ref: IN-DA001S4O

Apricitabine

CAS: 160707-69-7

Apricitabine

Purity: ≥98%

Molecular weight: 229.26g/mol

Ref: 54-BUP12670

(-)-2'-Deoxy-3'-oxa-4'-thiocytidine (Apricitabine)

Controlled Product

CAS: 160707-69-7

Applications (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (Apricitabine) is a drug that is used in the treatment of HIV aids. It as also been shown to be useful against lamivudine and zidovudine resistant virus strains
References Sebastian M., et al.: Org. Proc. Res. & Dev., 265, 763-773 (2011) Ghosh, R., et al.: Expert Opin. Pharmacother., 12, 31-46 (2011)

Formula: C₈H₁₁N₃O₃S

Color and Shape: Neat

Molecular weight: 229.25

Ref: TR-D245513

(-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine)

CAS: 160707-69-7

Apricitabine is a nucleoside analog that has been shown to be active against HIV. It inhibits HIV-1 reverse transcriptase by competing with the natural substrate, deoxycytidine triphosphate, and thereby prevents RNA synthesis. Apricitabine can be used for treatment of chronic hepatitis B or C virus infections, as well as long-term therapy for HIV infection. The drug has shown long-term efficacy in reducing viral load in patients receiving antiretroviral therapy, without causing significant toxicity. Apricitabine is not metabolized by cytochrome P450 enzymes and does not have significant interactions with other drugs. The drug binds to DNA in the cell nucleus and inhibits the process of DNA replication. The clinical use of apricitabine is limited by its short half-life (approximately 1 hour), which requires intravenous administration twice daily.

Formula: C₈H₁₁N₃O₃S

Purity: Min. 95%

Molecular weight: 229.26 g/mol

Ref: 3D-KGA70769

Apricitabine

CAS: 160707-69-7

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-

Formula: C₈H₁₁N₃O₃S

Purity: 99.45%

Color and Shape: Solid

Molecular weight: 229.26

Ref: TM-T14313