CAS 161710-10-7

GAMMA-SECRETASE INHIBITOR XII

Description:

Gamma-secretase inhibitor XII, identified by its CAS number 161710-10-7, is a chemical compound that plays a significant role in the study of Alzheimer's disease and other neurodegenerative disorders. This compound functions by inhibiting the gamma-secretase enzyme, which is crucial in the cleavage of amyloid precursor protein (APP) to produce amyloid-beta peptides. The accumulation of these peptides is associated with the pathogenesis of Alzheimer's disease. Characteristically, gamma-secretase inhibitor XII is a small organic molecule, often characterized by its specific structural features that allow it to interact with the active site of the gamma-secretase complex. Its efficacy and selectivity are important for minimizing off-target effects, which can lead to unwanted side effects. Research on this inhibitor contributes to the understanding of amyloidogenic pathways and aids in the development of therapeutic strategies aimed at reducing amyloid-beta production, thereby potentially altering the course of Alzheimer's disease. As with many pharmacological agents, the compound's solubility, stability, and bioavailability are critical factors influencing its therapeutic potential.

Formula: C₂₀H₃₀N₂O₄

Synonyms:

• Z-Ile-Leu-Aldehyde
• Z-Il-Cho

Z-Ile-Leu-aldehyde

CAS: 161710-10-7

Z-IL-CHO, a cell-permeable, reversible inhibitor, reduces amyloid β (Aβ)-production by blocking γ-secretase activity in vitro (Aβ₄₀ IC₅₀ = 7.9 µM; Aβ₄₂ IC₅₀ = 7.6 µM). Besides blocking the formation of Aβ the dipeptide aldehyde Z-IL-CHO also blocks the production of the γ-CTF (γ-secretase-generated carboxyl-terminal fragment), but does not affect the formation of amyloid-β-precursor protein (APP).

Formula: C₂₀H₃₀N₂O₄

Purity: > 97%

Color and Shape: White

Molecular weight: 362.47

Ref: 01-4048245

γ-SECRETASE INHIBITOR XII

CAS: 161710-10-7

Formula: C₂₀H₃₀N₂O₄

Purity: 97.28%

Molecular weight: 362.4632

Ref: IN-DA00AB8Y

Z-Ile-Leu-aldehyde

CAS: 161710-10-7

Z-Ile-Leu-aldehyde

Purity: 97%

Molecular weight: 362.47g/mol

Ref: 54-OR1068604

Z-Ile-Leu-aldehyde

CAS: 161710-10-7

Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.

Formula: C₂₀H₃₀N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 362.46

Ref: TM-T17281

Z-Ile-Leu-aldehyde

CAS: 161710-10-7

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Formula: C₂₀H₃₀N₂O₄

Purity: Min. 95%

Molecular weight: 362.46 g/mol

Ref: 3D-FI111102