CAS 162011-90-7
:Rofecoxib
Description:
Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It was primarily used for the treatment of osteoarthritis, rheumatoid arthritis, and acute pain conditions. Rofecoxib works by selectively inhibiting the COX-2 enzyme, which plays a key role in the inflammatory process, thereby reducing pain and inflammation with potentially fewer gastrointestinal side effects compared to traditional NSAIDs that inhibit both COX-1 and COX-2. The substance is characterized by its chemical formula, which includes a sulfonamide group, contributing to its pharmacological properties. However, Rofecoxib was withdrawn from the market in 2004 due to concerns about cardiovascular risks associated with its long-term use. Its pharmacokinetics indicate that it is well absorbed and has a long half-life, allowing for once-daily dosing. Despite its efficacy in pain management, the safety profile has led to significant scrutiny and regulatory action, highlighting the importance of balancing therapeutic benefits with potential risks in drug development.
Formula:C17H14O4S
InChI:InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
InChI key:InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N
SMILES:O=C1C(=C(CO1)C2=CC=C(S(C)(=O)=O)C=C2)C3=CC=CC=C3
Synonyms:- 2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-
- 3-(4-Methanesulfonylphenyl)-2-phenyl-2-buten-4-olide
- 3-Phenyl-4-[4-(Methylsulfonyl)phenyl]-2(5H)-furanone
- 4-(4-(Methanesulfonyl)phenyl)-3-phenyl-5H-furan-2-one
- 4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone
- 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
- Ceeoxx
- Ceoxx
- Mk 0966
- Mk 966
- Rhuma-cure
- Romacox
- Vioxx
- See more synonyms
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Found 11 products.
Rofecoxib
CAS:Formula:C17H14O4SPurity:>98.0%(GC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:314.364-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one
CAS:Formula:C17H14O4SPurity:99%Color and Shape:SolidMolecular weight:314.3557Rofecoxib
CAS:<p>Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins</p>Formula:C17H14O4SPurity:99.68% - 99.94%Color and Shape:Off-White (Pale Yellow) Crystalline PowderMolecular weight:314.36Rofecoxib
CAS:Formula:C17H14O4SPurity:≥ 99.0%Color and Shape:Yellow crystalline powderMolecular weight:314.36Vioxx
CAS:Controlled Product<p>Applications A selective cyclooxygenase-2 (COX-2) inhibitor. Use as an anti-inflammatory, analgesic.<br>References Catalla-Lawson, F., et al.: J. Pharmacol. Exp. Ther., 289, 735 (1999), Ehrich, E.W., et al.: Clin. Pharmacol. Ther., 65, 336 (1999), Langman, M.J., et al.: J. Am. Med. Assoc., 282, 1929 (1999),<br></p>Formula:C17H14O4SColor and Shape:NeatMolecular weight:314.36Rofecoxib - Bio-X ™
CAS:Controlled Product<p>Rofecoxib is a non-steroidal anti-inflammatory drug that is used to treat osteoarthritis, acute pain and migraine attacks. This drug is also a COX-2 inhibitor. As a result, it reduces inflammation and pain.</p>Formula:C17H14O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:314.36 g/molRofecoxib
CAS:Controlled Product<p>COX-2 inhibitor; a non-steroidal anti-inflammatory drug</p>Formula:C17H14O4SPurity:Min. 95%Color and Shape:White PowderMolecular weight:314.36 g/mol4-[4-(Methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
CAS:Formula:C17H14O4SPurity:99%(LC-MS);RGColor and Shape:SolidMolecular weight:314.36
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