CAS 162011-90-7: Rofecoxib

Description: Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It was primarily used for the treatment of osteoarthritis, rheumatoid arthritis, and acute pain conditions. Rofecoxib works by selectively inhibiting the COX-2 enzyme, which plays a key role in the inflammatory process, thereby reducing pain and inflammation with potentially fewer gastrointestinal side effects compared to traditional NSAIDs that inhibit both COX-1 and COX-2. The substance is characterized by its chemical formula, which includes a sulfonamide group, contributing to its pharmacological properties. However, Rofecoxib was withdrawn from the market in 2004 due to concerns about cardiovascular risks associated with its long-term use. Its pharmacokinetics indicate that it is well absorbed and has a long half-life, allowing for once-daily dosing. Despite its efficacy in pain management, the safety profile has led to significant scrutiny and regulatory action, highlighting the importance of balancing therapeutic benefits with potential risks in drug development.

Formula: C₁₇H₁₄O₄S

InChI: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

InChI key: InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N

SMILES: O=C1OCC(C=2C=CC(=CC2)S(=O)(=O)C)=C1C=3C=CC=CC3

Synonyms:

• 2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-
• 3-(4-Methanesulfonylphenyl)-2-phenyl-2-buten-4-olide
• 3-Phenyl-4-[4-(Methylsulfonyl)phenyl]-2(5H)-furanone
• 4-(4-(Methanesulfonyl)phenyl)-3-phenyl-5H-furan-2-one
• 4-[4-(Methylsulfonyl)-phenyl]-3-phenyl-2(5H)-furanone
• 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
• Ceeoxx
• Ceoxx
• Mk 0966
• Mk 966
• Rhuma-cure
• Romacox
• Vioxx
• Rofecoxib

Rofecoxib

CAS: 162011-90-7

• Formula: C₁₇H₁₄O₄S
• Purity: >98.0%(GC)
• Color and Shape: White to Yellow to Orange powder to crystal
• Molecular weight: 314.36

2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-

CAS: 162011-90-7

• Formula: C₁₇H₁₄O₄S
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 314.3557

Rofecoxib

CAS: 162011-90-7

Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition …

• Formula: C₁₇H₁₄O₄S
• Purity: 99.68% - 99.94%
• Color and Shape: Off-White (Pale Yellow) Crystalline Powder
• Molecular weight: 314.36

Rofecoxib

CAS: 162011-90-7

• Purity: 99%
• Molecular weight: 314.36g/mol

Rofecoxib

CAS: 162011-90-7

• Purity: 99.93%
• Molecular weight: 314.36g/mol

Rofecoxib

CAS: 162011-90-7

• Formula: C₁₇H₁₄O₄S
• Purity: ≥ 99.0%
• Color and Shape: Yellow crystalline powder
• Molecular weight: 314.36

Rofecoxib

CAS: 162011-90-7

• Formula: C₁₇H₁₄O₄S
• Color and Shape: Yellow Solid
• Molecular weight: 314.36

4-[4-(Methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one

CAS: 162011-90-7

• Purity: 98.0%
• Color and Shape: Solid
• Molecular weight: 314.3599853515625

Vioxx

CAS: 162011-90-7

Applications A selective cyclooxygenase-2 (COX-2) inhibitor. Use as an anti-inflammatory, analgesic. References Catalla-Lawson, F., et …

• Formula: C₁₇H₁₄O₄S
• Color and Shape: Neat
• Molecular weight: 314.36

Rofecoxib - Bio-X ™

CAS: 162011-90-7

Rofecoxib is a non-steroidal anti-inflammatory drug that is used to treat osteoarthritis, acute pain and …

• Formula: C₁₇H₁₄O₄S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 314.36 g/mol

Rofecoxib

CAS: 162011-90-7

COX-2 inhibitor; a non-steroidal anti-inflammatory drug

• Formula: C₁₇H₁₄O₄S
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 314.36 g/mol