CAS 16220-07-8
:allopurinol riboside
Description:
Allopurinol riboside, with the CAS number 16220-07-8, is a purine derivative that serves as a metabolite of allopurinol, a medication primarily used to treat gout and certain types of kidney stones by reducing uric acid levels. This compound is characterized by its structure, which includes a ribose sugar attached to the allopurinol moiety. Allopurinol riboside exhibits properties that may influence purine metabolism and has been studied for its potential biological activities, including effects on nucleic acid synthesis. It is soluble in water, which facilitates its biological interactions. The compound is of interest in pharmacological research, particularly in understanding the metabolic pathways of purine analogs and their therapeutic implications. As a metabolite, it may also play a role in the pharmacodynamics of allopurinol, contributing to its efficacy and side effects. Overall, allopurinol riboside represents a significant area of study in the context of purine metabolism and therapeutic applications in hyperuricemia-related conditions.
Formula:C10H12N4O5
InChI:InChI=1S/C10H12N4O5/c15-2-5-6(16)7(17)10(19-5)14-8-4(1-13-14)9(18)12-3-11-8/h1,3,5-7,10,15-17H,2H2,(H,11,12,18)/t5-,6-,7-,10-/m1/s1
InChI key:InChIKey=KFQUAMTWOJHPEJ-DAGMQNCNSA-N
SMILES:O[C@H]1[C@H](N2C3=C(C=N2)C(=O)N=CN3)O[C@H](CO)[C@H]1O
Synonyms:- 1,5-Dihydro-1-beta-D-ribofuranosyl-4H-pyrazolo(3,4-d)pyrimidin-4-one
- 1,5-Dihydro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one
- 1-(beta-D-ribofuranosyl)-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
- 1-(beta-L-ribofuranosyl)-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
- 1-[(2S,3S,4R,5R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl]-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (non-preferred name)
- 1-pentofuranosyl-1,2-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
- 4-Hydroxy(3,4-d)pyrazolopyrimidine riboside
- 4-Hydroxy-1beta-D-ribofuranosylpyrazolo(3,4-d)pyrimidine
- 4H-Pyrazolo(3,4-d)pyrimidin-4-one, 1,5-dihydro-1-beta-D-ribofuranosyl-
- 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- Allopurinol ribonucleoside
- Allopurinol-1-ribonucleoside
- NSC 252629
- Nsc 138437
- 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
- 1,5-Dihydro-1-β-D-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one
- See more synonyms
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Found 8 products.
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-β-D-ribofuranosyl-
CAS:Formula:C10H12N4O5Purity:98%Molecular weight:268.2261Allopurinol riboside
CAS:<p>Allopurinol riboside is a hydroxyl analog of allopurinol. Allopurinol riboside has minimal toxicity in tissue culture and exhibits no cytotoxicity in human serum. It is a potent inhibitor of microbial infection, including infections caused by Hepatitis C virus (HCV), Leishmania amazonensis, and Mycobacterium tuberculosis. Allopurinol riboside binds to adenine nucleotide and inhibits the synthesis of purines, which are necessary for DNA replication. This binding also inhibits the production of ATP, leading to cell death. In addition, allopurinol riboside inhibits the growth of human macrophages in vitro by inhibiting protein synthesis. Allopurinol riboside may be useful for treating HCV-induced liver disease or leishmaniasis.</p>Formula:C10H12N4O5Purity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:268.23 g/molAllopurinol riboside
CAS:Controlled ProductFormula:C10H12N4O5Color and Shape:NeatMolecular weight:268.226Allopurinol riboside
CAS:<p>Allopurinol riboside, an allopurinol metabolite, inhibits purine nucleoside phosphorylase in parasites with a Ki of 277 μM.</p>Formula:C10H12N4O5Purity:99.46% - 99.73%Color and Shape:SolidMolecular weight:268.23
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