CAS 1622902-68-4

N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide

Description:

N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide is a chemical compound characterized by its complex structure, which includes a cyclobutyl group, a sulfonamide functional group, and a pyrrolopyrimidine moiety. This compound is notable for its potential biological activity, particularly in medicinal chemistry, where it may serve as a lead compound for drug development. The presence of the sulfonamide group often contributes to the compound's solubility and ability to interact with biological targets, such as enzymes or receptors. The methyl group and the specific stereochemistry of the cyclobutyl ring can influence the compound's pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME). Additionally, the pyrrolopyrimidine structure is known for its role in various biological activities, making this compound of interest in the fields of pharmacology and drug design. As with many such compounds, further studies would be necessary to fully elucidate its mechanism of action and therapeutic potential.

Formula: C₁₄H₂₁N₅O₂S

InChI: InChI=1/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)/t10-,11+

InChI key: InChIKey=IUEWXNHSKRWHDY-PHIMTYICNA-N

SMILES: N(C)(C1=C2C(NC=C2)=NC=N1)[C@H]3C[C@@H](NS(CCC)(=O)=O)C3

Synonyms:

• PF 04965842
• 1-Propanesulfonamide, N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-
• N-[cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide
• Abrocitinib
• N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide

(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)methanol

CAS: 1622902-68-4

Formula: C₁₄H₂₁N₅O₂S

Purity: 99%

Color and Shape: Solid

Molecular weight: 323.4138

Ref: IN-DA01FW8P

N-(Cis-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)Cyclobutyl)Propane-1-Sulfonamide

CAS: 1622902-68-4

N-(Cis-3-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)Cyclobutyl)Propane-1-Sulfonamide

Purity: 98%

Molecular weight: 323.41g/mol

Ref: 54-OR1027826

Abrocitinib

CAS: 1622902-68-4

Abrocitinib

Purity: ≥98%

Molecular weight: 323.41g/mol

Ref: 54-BUP04940

Abrocitinib-d8

CAS: 1622902-68-4

Formula: C₁₄H₁₃D₈N₅O₂S

Molecular weight: 331.46

Ref: 4Z-A-300020

Abrocitinib

CAS: 1622902-68-4

Formula: C₁₄H₂₁N₅O₂S

Molecular weight: 323.42

Ref: 4Z-A-300001

Abrocitinib

CAS: 1622902-68-4

Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).

Formula: C₁₄H₂₁N₅O₂S

Purity: 99.09% - 99.91%

Color and Shape: Solid

Molecular weight: 323.41

Ref: TM-TQ0037

Abrocitinib

CAS: 1622902-68-4

Formula: C₁₄H₂₁N₅O₂S

Color and Shape: Neat

Ref: TR-A299840

PF-04965842

CAS: 1622902-68-4

PF-04965842 is an anti-inflammatory drug that belongs to the class of Jak1 inhibitors. It is used in the treatment of alopecia areata, dermatitis, and bowel disease. PF-04965842 is a selective inhibitor of JAK3 and blocks signaling through this pathway. PF-04965842 has been shown to have long-term efficacy in the treatment of inflammatory skin diseases such as atopic dermatitis and psoriasis. In addition, it has been demonstrated to be effective in reducing symptoms associated with inflammatory bowel disease (IBD) and ulcerative colitis. PF-04965842 also inhibits the production of proinflammatory cytokines by inhibiting the activation of inflammatory cells in the skin or gut.

Formula: C₁₄H₂₁N₅O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 323.41 g/mol

Ref: 3D-XPC90268