CAS 162758-35-2

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid

Description:

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, with CAS number 162758-35-2, is a chemical compound characterized by its pyrazole core, which is a five-membered ring containing two nitrogen atoms. This compound features multiple aromatic substituents, including a 4-chlorophenyl group and a 2,4-dichlorophenyl group, contributing to its potential biological activity and lipophilicity. The presence of a carboxylic acid functional group enhances its solubility in polar solvents and may influence its reactivity and interaction with biological targets. The chlorinated phenyl groups may also impart specific electronic properties, affecting the compound's pharmacokinetics and pharmacodynamics. This compound is of interest in medicinal chemistry and may exhibit herbicidal or fungicidal properties, making it relevant in agricultural applications. Its structural complexity and functional groups suggest potential for diverse interactions in biological systems, warranting further investigation into its efficacy and safety profiles.

Formula: C₁₇H₁₁Cl₃N₂O₂

InChI: InChI=1/C17H11Cl3N2O2/c1-9-15(17(23)24)21-22(14-7-6-12(19)8-13(14)20)16(9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,23,24)

InChI key: InChIKey=CYAYCOCJAVHQSD-UHFFFAOYSA-N

SMILES: Cc1c(C(=O)O)nn(c2ccc(cc2Cl)Cl)c1c1ccc(cc1)Cl

Synonyms:

• 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid
• 1H-Pyrazole-3-carboxylic acid, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-
• 5-(4-Chloro-Phenyl)-1-(2,4-Dichloro-Phenyl)-4-Methyl-1H-Pyrazole-3-Carboxylic Acid
• 5-(4-Chlorophenyl)-1-(2,4-Dichlorophenyl)-4-Methy-1H-Pyrazole-3-Carboxylic Acid
• 5-(4-Chlorophenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxylic Acid
• Rimonabant Carboxylic Acid
• Rimonabantacid
• Rimonabat Acomplia

1H-Pyrazole-3-carboxylic acid, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-

CAS: 162758-35-2

Formula: C₁₇H₁₁Cl₃N₂O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 381.6404

Ref: IN-DA001TE6

Rimonabant carboxylic acid

CAS: 162758-35-2

Rimonabant carboxylic acid

Purity: 98%

Molecular weight: 381.64g/mol

Ref: 54-OR1034452

5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid

CAS: 162758-35-2

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 381.6400146484375

Ref: 10-F041363

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid-13C,d7

Controlled Product

CAS: 162758-35-2

Formula: CC₁₆D₇H₄Cl₃N₂O₂

Color and Shape: Neat

Molecular weight: 389.676

Ref: TR-C377832

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid

Controlled Product

CAS: 162758-35-2

Applications 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid is used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists. It is metabolite M9 of Rimonabant (R517800), an antiobesity agent.
References Kang, S.Y. et al.: Bioorg. Med. Chem. Lett., 18, 2385 (2008); Fulp, A. et al.: Bioorg. Med. Chem. Lett., 21, 5711 (2011); Bergstrom, M.A. et al.: Drug Metab. and Dispos., 39, 1823 (2011);

Formula: C₁₇H₁₁Cl₃N₂O₂

Color and Shape: Neat

Molecular weight: 381.64

Ref: TR-C377830