CAS 1629268-00-3

1-[3-[4-[2-[[4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]-2-propen-1-one

CAS: 1629268-00-3

Formula: C₂₂H₂₉ClN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 432.9437

Ref: IN-DA01E2JY

ARS-853

CAS: 1629268-00-3

ARS-853

Purity: ≥95%

Molecular weight: 432.94g/mol

Ref: 54-BUP07398

ARS-853

CAS: 1629268-00-3

ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells

Formula: C₂₂H₂₉ClN₄O₃

Purity: 97.43% - 98.4%

Color and Shape: Solid

Molecular weight: 432.94

Ref: TM-T7414

ARS-853

Controlled Product

CAS: 1629268-00-3

Formula: C₂₂H₂₉ClN₄O₃

Color and Shape: Neat

Molecular weight: 432.944

Ref: TR-A774050

ARS-853

CAS: 1629268-00-3

ARS-853 is a potent inhibitor of protein kinase C (PKC) and PKC-related enzymes. ARS-853 has been shown to be an activated, potent inhibitor of PKC in vivo in a mouse tumor model. The mechanism of inhibition is thought to be due to the binding of ARS-853 to the catalytic site of PKC, which blocks phosphatase activity. PKC inhibitors are used in cancer treatment because they help control cancer cell signaling pathways. ARS-853 has been shown to inhibit phosphatases, such as PTP1B, which regulate multiple cellular processes including glycogen synthesis, lipid metabolism, and insulin secretion.
Pharmacokinetic studies have shown that ARS-853 is rapidly absorbed from the gastrointestinal tract and eliminated primarily by hepatic metabolism with a half-life of about 2 hours.

Formula: C₂₂H₂₉ClN₄O₃

Purity: Min. 95%

Molecular weight: 432.94 g/mol

Ref: 3D-EQC26800