CAS 1632006-28-0

Esaxerenone

Description:

Esaxerenone is a novel chemical compound primarily recognized for its role as a selective mineralocorticoid receptor antagonist (MRA). It is designed to treat conditions such as hypertension and heart failure by blocking the effects of aldosterone, a hormone that can lead to fluid retention and increased blood pressure. The molecular structure of Esaxerenone includes a unique arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, contributing to its pharmacological properties. It exhibits high selectivity for the mineralocorticoid receptor, which minimizes potential side effects associated with non-selective MRAs. Additionally, Esaxerenone has been shown to have a favorable pharmacokinetic profile, including good oral bioavailability and a manageable half-life, making it suitable for once-daily dosing. Its development reflects ongoing research into targeted therapies for cardiovascular diseases, aiming to improve patient outcomes while reducing adverse effects. As with any pharmaceutical agent, its efficacy and safety profile are evaluated through rigorous clinical trials before approval for clinical use.

Formula: C22H21F3N2O4S

InChI: InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)

InChI key: NOSNHVJANRODGR-UHFFFAOYSA-N

SMILES: CC1=C(N(C=C1C(=O)NC2=CC=C(C=C2)S(=O)(=O)C)CCO)C3=CC=CC=C3C(F)(F)F

Esaxerenone

CAS: 1632006-28-0

Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.

Formula: C₂₂H₂₁F₃N₂O₄S

Purity: 99.61%

Color and Shape: Solid

Molecular weight: 466.473

Ref: TM-T15246

(S)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide

CAS: 1632006-28-0

Formula: C₂₂H₂₁F₃N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 466.4733

Ref: IN-DA01EOE8

Esaxerenone

CAS: 1632006-28-0

Formula: C₂₂H₂₁F₃N₂O₄S

Molecular weight: 466.48

Ref: 4Z-E-219001

Esaxerenone

CAS: 1632006-28-0

Esaxerenone

Formula: C₂₂H₂₁F₃N₂O₄S

Purity: ≥98%

Molecular weight: 466.47

Ref: 54-BUP08696

Esaxerenone-d4

CAS: 1632006-28-0

Formula: C₂₂H₁₇D₄F₃N₂O₄S

Molecular weight: 470.50

Ref: 4Z-E-219002

Esaxerenone

CAS: 1632006-28-0

1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide

Formula: C₂₂H₂₁F₃N₂O₄S

Purity: 98%

Molecular weight: 466.47

Ref: IN-DG766807

Esaxerenone

CAS: 1632006-28-0

Formula: C₂₂H₂₁F₃N₂O₄S

Molecular weight: 466.5

Ref: BE-RMCE134000

Esaxerenone

CAS: 1632006-28-0

Formula: C₂₂H₂₁F₃N₂O₄S

Molecular weight: 466.48

Ref: ST-EA-CP-E185000

Esaxerenone

CAS: 1632006-28-0

Esaxerenone is a drug that is used to treat high blood pressure. It is an angiotensin receptor blocker (ARB) and is structurally related to the ACE inhibitor, perindopril. In vitro kinetic studies show that esaxerenone has a plasma concentration-time curve similar to perindopril, but with a longer half-life. Esaxerenone binds to the angiotensin II type 1 receptors in the kidneys and prevents the binding of angiotensin II, which causes vasoconstriction and increased blood pressure. Esaxerenone also inhibits the enzyme phosphodiesterase type 3, which increases levels of cAMP in cells and leads to relaxation of blood vessels. Esaxerenone may cause impotence, dizziness, or drowsiness as side effects due to its effect on the central nervous system.

Formula: C₂₂H₂₁F₃N₂O₄S

Purity: Min. 95%

Molecular weight: 466.47 g/mol

Ref: 3D-HQC00628