CAS 163252-36-6

clevudine

Description:

Clevudine is an antiviral nucleoside analog primarily investigated for its potential in treating chronic hepatitis B virus (HBV) infections. It is characterized by its structural similarity to naturally occurring nucleosides, which allows it to interfere with viral replication. Clevudine functions by inhibiting the viral polymerase enzyme, thereby preventing the synthesis of viral DNA. This compound is typically administered orally and has shown promise in clinical trials for its efficacy and safety profile. Its mechanism of action involves selective incorporation into viral DNA, leading to chain termination during replication. Clevudine is notable for its relatively favorable pharmacokinetic properties, including good bioavailability and a manageable half-life. However, like many antiviral agents, it may be associated with side effects, and resistance can develop with prolonged use. Ongoing research continues to evaluate its long-term effectiveness and potential role in combination therapies for HBV. Overall, clevudine represents a significant advancement in the pharmacological arsenal against hepatitis B.

Formula: C₁₀H₁₃FN₂O₅

InChI: InChI=1/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1

InChI key: InChIKey=GBBJCSTXCAQSSJ-XQXXSGGOSA-N

SMILES: F[C@H]1[C@H](O[C@@H](CO)[C@@H]1O)N2C(=O)NC(=O)C(C)=C2

Synonyms:

• 1-(2-Deoxy-2-fluoro-b-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2′-Deoxy-2′-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyluracil
• 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-
• 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-
• L-Fmau
• Levovir
• Clevudine
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-
• 1-(2′-Deoxy-2′-fluoro-β-L-arabinofuranosyl)-5-methyluracil
• Clevudine(Levovir)
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-BETA-L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-
• 1-(2''-DEOXY-2''-FLUORO--L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-[(2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-SS-L-ARABINOFURANOSYL)-5-METHYLURACIL
• CLEVUDINE, 1-(2'-DEOXY-2'-FLUORO-β-L-ARABINOFURANOSYL)-5-METHYLURACIL
• Clevudine USP/EP/BP
• 2'-Fluoro-5-methylarabinosyluracil
• 2'-F-2'-ara-dT

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-

CAS: 163252-36-6

Formula: C₁₀H₁₃FN₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 260.2190

Ref: IN-DA001TY5

Clevudine

CAS: 163252-36-6

Clevudine

Purity: 98%

Molecular weight: 260.22g/mol

Ref: 54-PC108998

Clevudine

CAS: 163252-36-6

Clevudine

Purity: ≥98%

Molecular weight: 260.22g/mol

Ref: 54-BUP06493

Clevudine

CAS: 163252-36-6

Formula: C₁₀H₁₃FN₂O₅

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 260.22

Ref: 7W-GP8280

Clevudine

CAS: 163252-36-6

Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.

Formula: C₁₀H₁₃FN₂O₅

Purity: 99.88% - 99.97%

Color and Shape: Solid

Molecular weight: 260.22

Ref: TM-T6446

Clevudine

CAS: 163252-36-6

Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.

Formula: C₁₀H₁₃FN₂O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 260.22 g/mol

Ref: 3D-NC09470

1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

CAS: 163252-36-6

Formula: C₁₀H₁₃FN₂O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 260.221

Ref: 10-F235704

Clevudine

Controlled Product

CAS: 163252-36-6

Applications Antiviral drug, used for the treatment of Hepatitis B.
References Kwon, S., et al.: J. Virol., 84, 4494 (2010), Daga, P., et al.: Protein Sci., 19, 796 (2010),

Formula: C₁₀H₁₃FN₂O₅

Color and Shape: Neat

Molecular weight: 260.22

Ref: TR-C574150