CAS 163680-77-1

Pazufloxaxin methanesulfonate

Description:

Pazufloxacin methanesulfonate is a synthetic fluoroquinolone antibiotic characterized by its broad-spectrum antibacterial activity. It is primarily used in the treatment of various bacterial infections, particularly those caused by Gram-negative and some Gram-positive organisms. The compound exhibits a mechanism of action that involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Pazufloxacin is known for its favorable pharmacokinetic properties, including good oral bioavailability and tissue penetration, which enhance its therapeutic efficacy. The methanesulfonate salt form improves its solubility and stability, making it suitable for formulation in various dosage forms. Additionally, pazufloxacin has been studied for its potential use in treating respiratory tract infections and urinary tract infections. As with other fluoroquinolones, it may be associated with side effects, including gastrointestinal disturbances and potential effects on tendon health. Overall, pazufloxacin methanesulfonate represents a valuable option in the antibiotic arsenal, particularly in the context of increasing antibiotic resistance.

Formula: C₁₇H₁₉FN₂O₇S

InChI: InChI=1/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1

InChI key: InChIKey=UDHGFPATQWQARM-FJXQXJEOSA-N

SMILES: O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O.S(C)(=O)(=O)O

Synonyms:

• (3S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Methanesulfonate
• (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
• (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, monomethanesulfonate (9CI)
• Pasil
• Pazucross
• Pazufloxacin Mesilate
• Pazufloxacin Mesylate
• Pazufloxacin Methanesulfonate
• T 3762
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,
• Pazufloxacin mesilate VETRANAL
• pazufloxaxin methanesulfonate
• Pazufloxacin Monomethanesulfonate
• 2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate
• (s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate
• (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,
• 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)
• Pazufloxacin mesylate, Pazufloxacin methanesulfonate
• PAZUFLOXAXIN METHANESULFONATE 99%

Pazufloxacin Mesylate

CAS: 127045-41-4, 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 414.40

Ref: 3B-P1962

(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5,7,9(13),11-tetraene-11-carboxylic acid; methanesulfonic acid

CAS: 163680-77-1

Formula: C₁₇H₁₉FN₂O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 414.4054

Ref: IN-DA001UB2

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Purity: 99.88% - 99.93%

Color and Shape: Crystalline Solid

Molecular weight: 414.4

Ref: TM-T1620

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Purity: ≥98%

Molecular weight: 414.4g/mol

Ref: 54-BUP14927

Pazufloxacin Mesylate

CAS: 163680-77-1

Pazufloxacin Mesylate

Purity: 98%

Molecular weight: 414.4g/mol

Ref: 54-PC109200

Pazufloxacin Mesylate

CAS: 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 318.31 96.11

Ref: 4Z-P-198001

PAZUFLOXACIN MESILATE

CAS: 163680-77-1

Purity: 95%

Molecular weight: 414.399993896484

Ref: 10-F806744

Pazufloxacin mesylate

CAS: 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Color and Shape: Neat

Molecular weight: 414.41

Ref: 04-C15896350

Pazufloxacin mesylate

CAS: 163680-77-1

Formula: C₁₆H₁₅FN₂O₄·CH₄SO₃

Molecular weight: 414.41

Ref: 7W-GA7060

Pazufloxacin Mesilate RS

CAS: 163680-77-1

Color and Shape: White To Pale Yellow-White Solid Crystalline Powder

Ref: 2K-1112800021

Pazufloxacin Mesylate

Controlled Product

CAS: 163680-77-1

Applications A fluorinated quinolone antibiotic. Antibacterial.
References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)

Formula: C₁₆H₁₅FN₂O₄·CH₄O₃S

Color and Shape: Neat

Molecular weight: 414.41

Ref: TR-P211000

Pazufloxacin mesylate

CAS: 163680-77-1

Pazufloxacin mesylate is an antimicrobial agent that inhibits bacterial growth by binding to bacterial DNA gyrase and topoisomerase IV. Pazufloxacin mesylate has been shown to have a synergistic effect with other antibiotics. It has been shown to be effective against a number of human pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae. Pazufloxacin mesylate is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. The inhibition of cell division by pazufloxacin mesilate may be due to the inhibition of rna synthesis and protein synthesis. This antibiotic also causes a decrease in locomotor activity in mice, which may be due to its ability to inhibit the release of inflammatory mediators

Formula: C₁₇H₁₉FN₂O₇S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 414.41 g/mol

Ref: 3D-FP26772