CAS 163706-06-7

Cangrelor

Description:

Cangrelor is a reversible P2Y12 platelet inhibitor used primarily in the management of acute coronary syndromes and during percutaneous coronary interventions. It is characterized by its rapid onset and offset of action, making it particularly useful in situations where immediate antiplatelet effects are required. As a nucleotide analog, Cangrelor binds to the P2Y12 receptor on platelets, preventing ADP-mediated activation and aggregation. Its pharmacokinetics are notable for a short half-life, which allows for quick recovery of platelet function after discontinuation. Cangrelor is administered intravenously, which facilitates precise control over dosing and rapid adjustments based on clinical needs. The substance is generally well-tolerated, though potential side effects may include bleeding complications, which are common with antiplatelet therapies. Overall, Cangrelor represents a significant advancement in antiplatelet therapy, particularly in acute care settings where timing and efficacy are critical.

Formula: C₁₇H₂₅Cl₂F₃N₅O₁₂P₃S₂

InChI: InChI=1S/C17H25Cl2F3N5O12P3S2/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32)/t8-,10-,11-,14-/m1/s1

InChI key: InChIKey=PAEBIVWUMLRPSK-IDTAVKCVSA-N

SMILES: N(CCSC)C1=C2C(N(C=N2)[C@@H]3O[C@H](COP(OP(C(P(=O)(O)O)(Cl)Cl)(=O)O)(=O)O)[C@@H](O)[C@H]3O)=NC(SCCC(F)(F)F)=N1

Synonyms:

• 5′-Adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P′-(dichloromethylene)bis[phosphonic acid] (1:1)
• 5′-Adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, monoanhydride with (dichloromethylene)bis[phosphonic acid]
• Ar-C 69931
• Cangerlor
• Cangrelor
• Kengreal
• Kengrexal
• Zinc 85537017
• adenosine, 5'-O-[[[(dichlorophosphonomethyl)hydroxyphosphinyl]oxy]hydroxyphosphinyl]-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-
• 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]-N-[2-(methylsulfanyl)ethyl]-2-[(3,3,3-trifluoropropyl)sulfanyl]adenosine
• AR-C69931 (Cangrelor)
• Cangrelor (Crude) Q: What is the CAS Number of
• Cangrelor 13CD7
• Cangrelor (Crude)Q: What is
• 163706-06-7 CANGRELOR
• Cangrelor (AR-C69931)
• Cangrelor (Crude) Q: What is the storage condition of
• 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(...
• Cangrelor sodium
• Cangrelor free acid
• Cangrelor 13CD3
• N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-5'-adenylic acid anhydride with P,P'-(dichloromethylene)bis[phosphonic acid]
• CANGRELOR;ARC69931;ARC 69931
• [dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid

Cangrelor free acid

CAS: 163706-06-7

Cangrelor, a reversible P2Y12 inhibitor for IV use, was approved in June 2015; it rapidly blocks ADP-induced platelet aggregation.

Formula: C₁₇H₂₅Cl₂F₃N₅O₁₂P₃S₂

Color and Shape: Solid

Molecular weight: 776.36

Ref: TM-T70335

Cangrelor

Controlled Product

CAS: 163706-06-7

Formula: C₁₇H₂₅Cl₂F₃N₅O₁₂P₃S₂

Color and Shape: Neat

Molecular weight: 776.359

Ref: TR-C175230

Cangrelor

CAS: 163706-06-7

Formula: C₁₇H₂₅Cl₂F₃N₅O₁₂P₃S₂

Molecular weight: 776.35

Ref: ST-EA-CP-C114000