CAS 164650-44-6

Efinaconazole

Description:

Efinaconazole is an antifungal agent primarily used in the treatment of onychomycosis, a fungal infection of the nails. It belongs to the class of triazole antifungals and works by inhibiting the enzyme lanosterol 14α-demethylase, which is crucial for the synthesis of ergosterol, an essential component of fungal cell membranes. Efinaconazole is characterized by its high lipophilicity, allowing it to penetrate the nail plate effectively. It is typically formulated as a topical solution, which facilitates direct application to the affected area. The substance is known for its favorable pharmacokinetic profile, including a low systemic absorption rate, which minimizes potential side effects. Efinaconazole is generally well-tolerated, with the most common adverse effects being localized reactions at the application site. Its efficacy and safety profile make it a preferred choice for treating nail fungal infections, providing a non-invasive alternative to systemic therapies.

Formula: C₁₈H₂₂F₂N₄O

InChI: InChI=1S/C18H22F2N4O/c1-13-5-7-23(8-6-13)14(2)18(25,10-24-12-21-11-22-24)16-4-3-15(19)9-17(16)20/h3-4,9,11-12,14,25H,1,5-8,10H2,2H3/t14-,18-/m1/s1

InChI key: InChIKey=NFEZZTICAUWDHU-RDTXWAMCSA-N

SMILES: [C@@]([C@@H](C)N1CCC(=C)CC1)(CN2C=NC=N2)(O)C3=C(F)C=C(F)C=C3

Synonyms:

• (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(4H-1,3,4-triazol-4-yl)butan-2-ol
• (R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
• (αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
• 1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-
• 1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, [R-(R*,R*)]-
• Jublia
• KP 103 (pharmaceutical)
• Kp-103
• Efinaconzole
• JUBLIA; KP 103; KP103
• (alphaR,betaR)-alpha-(2,4-Difluorophenyl)-beta-methyl-4-methylene-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol
• Efinaconazole Q: What is the CAS Number of
• Efinaconazole D4
• Efinaconazole 13CD2
• (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
• Efinaconazole D4 Q: What is the CAS Number of
• EfinaconazoleQ: What is
• Efinaconazole
• Efinaconazole Q: What is the storage condition of
• KP 103 USP/EP/BP
• Efinaconazole In-House
• (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (Efinaconazole)
• Efluconazole
• Efinaconazole 13CD6
• Efinaconazole(KP 103)
• Efinaconazole D4Q: What is

1-Piperidineethanol, α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αR,βR)-

CAS: 164650-44-6

Formula: C₁₈H₂₂F₂N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 348.3903

Ref: IN-DA001V0H

(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-Methylenepiperidin-1-yl)-1-(1H-1,2,4-Triazol-1-yl)Butan-2-ol

CAS: 164650-44-6

(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-Methylenepiperidin-1-yl)-1-(1H-1,2,4-Triazol-1-yl)Butan-2-ol

Purity: 98%

Molecular weight: 348.39g/mol

Ref: 54-PC104927

Efinaconazole

CAS: 164650-44-6

Efinaconazole

Purity: ≥95%

Molecular weight: 348.39g/mol

Ref: 54-BUP13306

Efinaconazole-d4

CAS: 164650-44-6

Formula: C₁₈H₁₈D₄F₂N₄O

Color and Shape: White To Off-White Solid

Molecular weight: 352.42

Ref: 4Z-E-097009

Efinaconazole

CAS: 164650-44-6

Formula: C₁₈H₂₂F₂N₄O

Color and Shape: White To Off-White Solid

Molecular weight: 348.40

Ref: 4Z-E-097001

Efinaconazole

CAS: 164650-44-6

Efinaconazole (KP-103)(KP-103) is an Azole Antifungal currently under development as a topical treatment for onychomycosis.

Formula: C₁₈H₂₂F₂N₄O

Purity: 97.34% - 98%

Color and Shape: Solid

Molecular weight: 348.39

Ref: TM-T2333

(2S,3R)-Efinaconazole

Controlled Product

CAS: 164650-44-6

Applications (2S,3R)-Efinaconazole is the 2S,3R-enantiomer of Efinaconazole (E435070); a topical antifungal for onychomycosis.
References Sugiura, K., et. al.: Antimicrob. Agents CH., 58, 3837 (2014)

Formula: C₁₈H₂₂F₂N₄O

Color and Shape: Neat

Molecular weight: 348.39

Ref: TR-E435085

Efinaconazole

Controlled Product

CAS: 164650-44-6

Applications Efinaconazole is a topical antifungal for onychomycosis. (Synonyms: KP-103)
References Sugiura, K., et. al.: Antimicrob. Agents CH., 58, 3837 (2014);

Formula: C₁₈H₂₂F₂N₄O

Color and Shape: Neat

Molecular weight: 348.39

Ref: TR-E435070

Efinaconazole

CAS: 164650-44-6

Efinaconazole is a triazole antifungal agent with action on fungal 14α-demethylase to inhibit ergosterol synthesis and is used for treating onychomycosis (fungal nail infections).

Formula: C₁₈H₂₂F₂N₄O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 348.39 g/mol

Ref: 3D-FD58714

(2R,3R)-2-(2,4-DIFLUOROPHENYL)-3-(4-METHYLENEPIPERIDIN-1-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL

CAS: 164650-44-6

Formula: C₁₈H₂₂F₂N₄O

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 348.398

Ref: 10-F466806

Efinaconazole-d4

Controlled Product

CAS: 164650-44-6

Formula: C₁₈D₄H₁₈F₂N₄O

Color and Shape: Neat

Molecular weight: 352.415

Ref: TR-E435072

Efinaconazole

CAS: 164650-44-6

Formula: C₁₈H₂₂F₂N₄O

Color and Shape: Neat

Molecular weight: 348.39

Ref: 04-C13111200