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CAS 165800-06-6

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Zoledronic acid hydrate

Description:
Zoledronic acid hydrate is a bisphosphonate compound primarily used in the treatment of osteoporosis and various bone-related conditions, including hypercalcemia associated with malignancies. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The substance is typically administered intravenously and has a high affinity for bone tissue. In its hydrate form, it contains water molecules that are integrated into its crystalline structure, which can influence its solubility and stability. Zoledronic acid is characterized by its complex molecular structure, which includes a nitrogen-containing heterocycle, contributing to its potency and efficacy. The compound is generally well-tolerated, although it may cause side effects such as flu-like symptoms, gastrointestinal issues, and, in rare cases, osteonecrosis of the jaw. Its pharmacokinetics involve rapid distribution to bone and a long half-life, allowing for less frequent dosing compared to other bisphosphonates. Overall, zoledronic acid hydrate plays a significant role in managing bone health in various clinical settings.
Formula:C5H12N2O8P2
InChI:InChI=1/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
SMILES:c1cn(CC(O)(P(=O)(O)O)P(=O)(O)O)cn1.O
Synonyms:
  • [1-Hydroxy-(1H-Imidazol-1-Yl)-Phosphonoethyl] Phosphonic Acid Monohydrate
  • (1-Hydroxy-2-Imidazol-1-Yl-1-Phosphono-Ethyl)Phosphonic Acid Hydrate
  • (1-Hydroxy-2-Imidazol-1-Ylethylidene)Diphosphonic Acid Monohydrate
  • Phosphonic Acid, [1-Hydroxy-2-(1H-Imidazol-1-Yl)Ethylidene]Bis-, Monohydrate
  • Zoledronic Acid Monohydrate
  • ZoledronicacidforInjection
  • [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1)
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