CAS 16590-41-3

Naltrexone

Description:

Naltrexone is an opioid antagonist primarily used in the management of opioid dependence and alcohol use disorder. It functions by blocking the effects of opioids at the receptor level, thereby reducing cravings and the euphoric effects associated with opioid use. Naltrexone is a white to off-white crystalline powder that is soluble in water and has a molecular formula of C20H23NO4. Its mechanism of action involves competitive inhibition of the mu-opioid receptors, which helps to prevent relapse in individuals recovering from opioid addiction. The substance is typically administered in oral form or via intramuscular injection, with a long half-life that allows for once-daily dosing in oral formulations or less frequent dosing in injectable forms. Side effects may include nausea, headache, dizziness, and fatigue, but it is generally well-tolerated. Due to its opioid-blocking properties, naltrexone is contraindicated in patients currently using opioids, as it can precipitate withdrawal symptoms. Overall, naltrexone plays a significant role in addiction treatment protocols.

Formula: C₂₀H₂₃NO₄

InChI: InChI=1/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19?,20-/m1/s1

InChI key: InChIKey=DQCKKXVULJGBQN-XFWGSAIBSA-N

SMILES: O[C@]12[C@@]34C=5C(O[C@]3(C(=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC6CC6)CC4)[H]

Synonyms:

• (1S,5R,13R,17S)-4-(Cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadeca-7(18),8,10-trien-14-on
• (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadeca-7(18),8,10-trien-14-one
• (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
• (5alpha)-17-(Cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-one
• 1-N-Cyclopropylmethyl-7,8-dihydro-14-hydroxynormorphinone
• 16590-41-3
• Depotrex
• En 1639
• En 1639A
• Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5α)-
• Morphinan-6-one, 17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-
• N-Cyclopropylmethylnoroxymorphone
• Naltrel
• Naltrexon
• Naltrexona
• Nemexin
• ReVia
• Trexonil
• Um 792
• Vivitrex
• Vivitrol
• Naltrexone Hydrochloride Impurity 1
• Naltrexone USP/EP/BP
• Naltrexone (200 mg)
• trexan
• Naltrexone (1.0 mg/mL in Methanol)
• Naltrexone Base & HCL
• 3,14-Dihydroxy-17-(cyclopropylmethyl)-4,5α-epoxymorphinan-6-one
• Naltrexone, 1.0 mg/mL
• en1939
• en1639
• Naltrexone trifluoroacetate salt
• NALTREXONE10G
• Naltrexone (base and/or unspecified salts)
• (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one
• Naltrexone impurty
• NaltrexoneBase
• NALTREXONE
• Naltrexone (base, anhydrous)
• celupan
• 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
• 4,5α-Epoxy-3,14β-dihydroxy-17-(cyclopropylmethyl)morphinan-6-one
• C07253
• 17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-on
• n-cyclopropylmethyl-14-hydroxydihydromorphinone
• Naltrexone (controlled) HCl
• Naltrexone solution
• 5-epoxy-3,14-dihydroxy-17-(cyclopropylmethyl)-(5-alpha)-morphinan-6-on

NALTREXONE

CAS: 16590-41-3

NALTREXONE

Purity: 97%

Color and Shape: Solid

Molecular weight: 341.4070129

Ref: 10-F857764

Naltrexone

CAS: 16590-41-3

Alkaloids of opium and their derivatives, salts thereof

Formula: C₂₀H₂₃NO₄

Color and Shape: Tan Off-White Powder

Molecular weight: 341.4

Ref: 45-1453504

Naltrexone

CAS: 16590-41-3

Formula: C₂₀H₂₃NO₄

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 341.40

Ref: 7W-GP4647

Naltrexone

Controlled Product

CAS: 16590-41-3

Formula: C₂₀H₂₃NO₄

Color and Shape: Neat

Molecular weight: 341.4

Ref: 86-MM0233.04

Naltrexone

Controlled Product

CAS: 16590-41-3

Applications Naltrexone is an opioid antagonist shown to reduce the occurrence of addictive behaviours such as eating, smoking and drinking excessively. in addition to curbing drug use it has recently been used in flavor avoidance studies.
References Mannelli, P. et al.: Drug Alc. Dep. 138, 83 (2014); Rotella, F. et al.: 128, 133 (2014);

Formula: C₂₀H₂₃NO₄

Color and Shape: Neat

Molecular weight: 341.4

Ref: TR-N285745

Naltrexone-[d4]

CAS: 16590-41-3

Formula: C₂₀H₂₃NO₄

Color and Shape: Solid

Molecular weight: 341.4

Ref: BE-MD-7889

Naltrexone

CAS: 16590-41-3

Formula: C₂₀H₂₃NO₄

Color and Shape: Solid

Molecular weight: 341.4

Ref: BE-MU-7889

Naltrexone (1 mg/mL in Methanol)

Controlled Product

CAS: 16590-41-3

Formula: C₂₀H₂₃NO₄

Color and Shape: Single Solution

Molecular weight: 341.40

Ref: TR-KIT7810

1-Chloro Naltrexone

Controlled Product

CAS: 16590-41-3

Formula: C₂₀H₂₂ClNO₄

Color and Shape: Neat

Molecular weight: 375.85

Ref: TR-C375265

Naltrexone

CAS: 16590-41-3

Formula: C₂₀H₂₃NO₄

Molecular weight: 341.4

Ref: ST-EA-CP-N57000